公开(公告)号：EP2857459A1

公开(公告)日：2015-04-08

申请号：EP13780703.8

申请日：2013-04-30

申请人： Kowa Company Ltd.

发明人： TAMURA, Masahiro ,  OSHITA, Takahide

IPC分类号： C09B29/12 ,  A61F2/16 ,  A61L27/00 ,  C08F20/56

CPC分类号： C07C245/08 ,  A61F2/16 ,  A61F2002/16965 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/16 ,  C08F220/00 ,  C08F220/60 ,  C08F220/68 ,  C09B29/0003 ,  C09B29/12 ,  C09B69/106 ,  C08L33/26

摘要： A polymerizable UV-absorbing colorant monomer is provided, which is excellent in stability under alkaline conditions and which is available for a useful material polymer for an intraocular lens. A compound, which is represented by the following general formula (1), is used as a polymerizable UV-absorbing monomer available for a material polymer for an intraocular lens:

(in the general formula (1), R 1 is a hydrogen atom, a hydroxy group, a carboxy group, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a sulfonic acid group, or a benzyloxy group, R 2 is a hydrogen atom, a hydroxy group, or an alkoxy group having 1 to 4 carbon atoms, and R 3 is represented by the following formula (2)):
(in the general formula (2), R 4 is a hydrogen atom or a methyl group, and R 5 is a single bond or an alkylene group having 1 to 4 carbon atoms which may have a substituent or

substituents.)

摘要翻译： 提供可聚合的UV吸收着色剂单体，其在碱性条件下的稳定性优异，并且可用于人造眼镜的有用材料聚合物。 使用由以下通式（1）表示的化合物作为可用于眼内透镜的材料聚合物的可聚合的UV吸收单体：（在通式（1）中，R 1为氢原子， 羟基，羧基，碳原子数1〜8的烷基，碳原子数1〜8的烷氧基，磺酸基或苄氧基，R 2为氢原子，羟基或 具有1至4个碳原子的烷氧基，R 3由下式（2）表示）：（通式（2）中，R 4为氢原子或甲基，R 5为单 键或可以具有取代基的具有1至4个碳原子的亚烷基。）

公开(公告)号：EP2380877A1

公开(公告)日：2011-10-26

申请号：EP09829208.9

申请日：2009-11-27

申请人： Kowa Company, Ltd.

发明人： KITAMURA, Takahiro ,  YAMADA, Hajime ,  TAKEMURA, Shunji ,  ASHIKAWA, Masanori ,  ISHIKAWA, Tetsuya ,  MIYAKE, Yoshiharu ,  KOUKETSU, Akiyasu ,  SATO, Seiichi ,  ISHIWATA, Hiroyuki ,  TABUNOKI, Yuichiro ,  SHIBASAKI, Manabu ,  OZAWA, Takatoshi ,  SHIGEMI, Ryota ,  DOI, Takeshi ,  TAMURA, Masahiro

IPC分类号： C07D213/82 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/04 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1):

or its salt or a solvate thereof.

摘要翻译： 提供一种新型的JAK3抑制剂，其可用作器官移植，类风湿性关节炎，多发性硬化症，系统性红斑狼疮，舍格伦综合征，白塞病，I型糖尿病的排斥和移植物抗宿主病（GvHD）的预防和/或治疗剂 自身免疫性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩氏病，哮喘，变应性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，变应性结膜炎，葡萄膜炎，癌症，白血病等。 由通式（1）表示的吡啶-3-羧酰胺衍生物或其盐或其溶剂化物。

公开(公告)号：EP2857459B1

公开(公告)日：2017-12-27

申请号：EP13780703.8

申请日：2013-04-30

申请人： Kowa Company, Ltd.

发明人： TAMURA, Masahiro ,  OSHITA, Takahide

IPC分类号： C09B29/12 ,  A61F2/16 ,  A61L27/00 ,  C08F20/56

CPC分类号： C07C245/08 ,  A61F2/16 ,  A61F2002/16965 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/16 ,  C08F220/00 ,  C08F220/60 ,  C08F220/68 ,  C09B29/0003 ,  C09B29/12 ,  C09B69/106 ,  C08L33/26

摘要： A polymerizable UV-absorbing colorant monomer is provided, which is excellent in stability under alkaline conditions and which is available for a useful material polymer for an intraocular lens. A compound, which is represented by the following general formula (1), is used as a polymerizable UV-absorbing monomer available for a material polymer for an intraocular lens: (in the general formula (1), R 1 is a hydrogen atom, a hydroxy group, a carboxy group, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a sulfonic acid group, or a benzyloxy group, R 2 is a hydrogen atom, a hydroxy group, or an alkoxy group having 1 to 4 carbon atoms, and R 3 is represented by the following formula (2)): (in the general formula (2), R 4 is a hydrogen atom or a methyl group, and R 5 is a single bond or an alkylene group having 1 to 4 carbon atoms which may have a substituent or substituents.)