ADSORBENT FOR ORAL ADMINISTRATION, THERAPEUTIC AGENT FOR RENAL DISEASES AND THERAPEUTIC AGENT FOR HEPATIC DISEASES
    4.
    发明公开
    ADSORBENT FOR ORAL ADMINISTRATION, THERAPEUTIC AGENT FOR RENAL DISEASES AND THERAPEUTIC AGENT FOR HEPATIC DISEASES 审中-公开
    口服给药吸收剂,肾病治疗剂和肝病治疗剂

    公开(公告)号:EP3187187A1

    公开(公告)日:2017-07-05

    申请号:EP15836868.8

    申请日:2015-08-27

    摘要: An object of the present invention is to provide an adsorbent for oral administration capable of adsorbing large quantities of indole in the presence of bile acid.
    The above problem can be solved by an adsorbent for oral administration comprising a spherical activated carbon, the activated carbon having a specific surface area determined by the BET method of 800 m 2 /g or more, a bulk density of from 0.3 g/mL to 0.8 g/mL, a volume of pores having a diameter less than 3 nm of 0.3 mL/g or more, and a micropore/mesopore ratio (Vm) determined by Formula (1): Vm = Vmic/Vmet (1) wherein Vmic is a volume of pores having a diameter less than 3 nm, and Vmet is a volume of pores having a diameter from 3 nm to 50 nm; of 3.0 or more.

    摘要翻译: 本发明的一个目的是提供一种能在胆汁酸存在下吸附大量吲哚的口服吸附剂。 上述问题可通过含有球形活性炭的口服用吸附剂解决,所述活性炭具有通过BET方法测定的比表面积为800m 2 / g或更高,堆积密度为0.3g / mL至0.8 g / mL,直径小于3nm的孔的体积为0.3mL / g以上,由式(1)决定的微孔/中孔率(Vm):Vm = Vmic / Vmet 一定体积的直径小于3nm的孔隙,Vmet是直径为3nm至50nm的孔隙体积; 为3.0或更多。