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公开(公告)号：EP2275414B1
公开(公告)日：2015-06-10
申请号：EP09738624.7
申请日：2009-04-27
IPC分类号： C07D277/20 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/437 , A61K31/44 , A61K31/454 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61P3/10 , A61P43/00 , C07D213/75 , C07D231/38 , C07D241/20 , C07D261/14 , C07D277/44
CPC分类号： C07C309/77 , C07C2601/02 , C07C2601/08 , C07D213/75 , C07D231/38 , C07D241/20 , C07D261/14 , C07D277/20 , C07D277/44 , C07D277/82 , C07D285/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/12 , C07D513/04 , C07F9/5442 , C07F9/650964 , C07F9/6539
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公开(公告)号：EP2275414A1
公开(公告)日：2011-01-19
申请号：EP09738624.7
申请日：2009-04-27
IPC分类号： C07D277/20 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/437 , A61K31/44 , A61K31/454 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61P3/10 , A61P43/00 , C07D213/75 , C07D231/38 , C07D241/20 , C07D261/14 , C07D277/44
CPC分类号： C07C309/77 , C07C2601/02 , C07C2601/08 , C07D213/75 , C07D231/38 , C07D241/20 , C07D261/14 , C07D277/20 , C07D277/44 , C07D277/82 , C07D285/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/12 , C07D513/04 , C07F9/5442 , C07F9/650964 , C07F9/6539
摘要： A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1):
(wherein R 1 and R 2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C 1 to C 6 alkyl group, a C 1 to C 6 alkoxy group, a C 1 to C 6 alkylsulfonyl group, a C 1 to C 6 alkylsulfinyl group, a C 1 to C 6 alkylsulfonyl group, or a C 1 to C 6 alkoxy-C 1 to C 6 alkylsulfonyl group, and A is a substituted or unsubstituted heteroaryl group).摘要翻译： 提供了具有降血糖作用的化合物。 该化合物及其药学上可接受的盐可用于治疗或预防糖尿病，肥胖症等。 该化合物由通式（1）表示：（其中R1和R2各自独立地为氢原子，卤素原子，氨基，羟基，羟基氨基，硝基，氰基，氨磺酰基 C1-C6烷基，C1-C6烷氧基，C1-C6烷基磺酰基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基或C1-C6烷氧基-C1-C6烷基磺酰基， A是取代或未取代的杂芳基）。
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公开(公告)号：EP2116533A1
公开(公告)日：2009-11-11
申请号：EP08721434.2
申请日：2008-03-06
发明人： FUKUDA, Yasumichi , ASAHINA, Yoshikazu , TAKADOI, Masanori , OHATA, Kohei , IDE, Tomohiro , KOBAYASHI, Fumiyoshi , KOBAYASHI, Shinji , KOMATSU, Kanji , YAMAMOTO, Masanori
IPC分类号： C07D213/75 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/437 , A61K31/4965 , A61P3/04 , A61P3/10 , A61P43/00 , C07D231/38 , C07D241/20 , C07D263/14 , C07D277/20 , C07D277/46 , C07D277/56 , C07D285/12
CPC分类号： C07D277/46 , C07C317/44 , C07C2601/02 , C07C2601/08 , C07D213/75 , C07D231/40 , C07D241/20 , C07D261/14 , C07D277/82 , C07D285/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D417/04 , C07D498/04 , C07D513/04
摘要： A compound, or a pharmaceutically acceptable salt thereof, represented by the formula (1),
(wherein, the carbon atom marked with an * is in the R-configuration, R 1 represents a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C 1 -C 6 alkyl group, or a C 1 -C 6 alkoxy group, R 2 represents a C 3 -C 6 cycloalkylsulfanyl group, a C 3 -C 6 cycloalkylsulfinyl group, or a C 3 -C 6 cycloalkylsulfonyl group, and A represents a substituted or unsubstituted heteroaryl group).-
公开(公告)号：EP2116535B1
公开(公告)日：2014-06-11
申请号：EP07851044.3
申请日：2007-12-21
发明人： FUKUDA, Yasumichi , ASAHINA, Yoshikazu , NAKAMURA, Ayako , FUJITA, Kenji , IDE, Tomohiro , KOBAYASHI, Fumiyoshi , KOBAYASHI, Shinji , KOMATSU, Kanji , YAMAMOTO, Masanori
IPC分类号： C07D213/75 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/437 , A61K31/4965 , A61P3/04 , A61P3/10 , A61P43/00 , C07D231/38 , C07D241/20 , C07D263/14 , C07D277/20 , C07D277/46 , C07D277/56 , C07D285/12 , C07D217/22 , C07D231/40 , C07D213/80
CPC分类号： C07C317/44 , C07C2601/08 , C07D213/75 , C07D213/80 , C07D215/38 , C07D217/22 , C07D231/40 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/28 , C07D241/44 , C07D261/14 , C07D263/48 , C07D275/02 , C07D277/20 , C07D277/46 , C07D277/82 , C07D285/08 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
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公开(公告)号：EP2116533B1
公开(公告)日：2013-07-10
申请号：EP08721434.2
申请日：2008-03-06
发明人： FUKUDA, Yasumichi , ASAHINA, Yoshikazu , TAKADOI, Masanori , OHATA, Kohei , IDE, Tomohiro , KOBAYASHI, Fumiyoshi , KOBAYASHI, Shinji , KOMATSU, Kanji , YAMAMOTO, Masanori
IPC分类号： C07D213/75 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/437 , A61K31/4965 , A61P3/04 , A61P3/10 , A61P43/00 , C07D231/38 , C07D241/20 , C07D263/14 , C07D277/20 , C07D277/46 , C07D277/56 , C07D285/12
CPC分类号： C07D277/46 , C07C317/44 , C07C2601/02 , C07C2601/08 , C07D213/75 , C07D231/40 , C07D241/20 , C07D261/14 , C07D277/82 , C07D285/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D417/04 , C07D498/04 , C07D513/04
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公开(公告)号：EP2116535A1
公开(公告)日：2009-11-11
申请号：EP07851044.3
申请日：2007-12-21
发明人： FUKUDA, Yasumichi , ASAHINA, Yoshikazu , NAKAMURA, Ayako , FUJITA, Kenji , IDE, Tomohiro , KOBAYASHI, Fumiyoshi , KOBAYASHI, Shinji , KOMATSU, Kanji , YAMAMOTO, Masanori
IPC分类号： C07D213/80 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/455 , A61K31/47 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/505
CPC分类号： C07C317/44 , C07C2601/08 , C07D213/75 , C07D213/80 , C07D215/38 , C07D217/22 , C07D231/40 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/28 , C07D241/44 , C07D261/14 , C07D263/48 , C07D275/02 , C07D277/20 , C07D277/46 , C07D277/82 , C07D285/08 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： A compound represented by the following formula (1):
(wherein the carbon atom denoted by * is in the R-configuration; R 1 and R 2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C 1 -C 6 alkyl group, a C 1 -C 6 alkoxy group, a C 1 -C 6 alkylsulfanyl group, a C 1 -C 6 alkylsulfinyl group or a C 1 -C 6 alkylsulfonyl group; andA is a substituted or unsubstituted heteroaryl group), or a pharmaceutically acceptable salt thereof.
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