公开(公告)号：EP4397766A1

公开(公告)日：2024-07-10

申请号：EP22864632.9

申请日：2022-08-31

申请人： Kyoto University

发明人： TOMONAGA, Keizo ,  MAKINO, Akiko ,  SAKAI, Madoka ,  KOMORIZONO, Ryo ,  URUSHITANI, Makoto ,  MORIMURA, Toshifumi ,  MINAMIYAMA, Sumio

IPC分类号： C12N15/86 ,  A61K35/76 ,  A61P21/02 ,  C12N5/10 ,  C12N7/01 ,  C07K16/40 ,  C07K16/46 ,  C12N15/13

CPC分类号： A61K35/76 ,  A61P21/02 ,  C07K16/00 ,  C07K16/40 ,  C07K16/46 ,  C12N7/00 ,  C12N5/10 ,  C12N15/86

摘要： Disclosed are a bornavirus vector comprising a nucleic acid encoding an antibody or antibody fragment capable of binding to a mutant SOD1 protein, the antibody or antibody fragment comprising a heavy-chain variable region comprising a heavy-chain CDR1 consisting of an amino acid sequence GFSLNTSGMG (SEQ ID NO: 1), a heavy-chain CDR2 consisting of an amino acid sequence IWWDDDK (SEQ ID NO: 2), and a heavy-chain CDR3 consisting of an amino acid sequence ARLGYAMDY (SEQ ID NO: 3), the heavy-chain variable region optionally having 3 or fewer amino acid substitutions, and/or a light-chain variable region comprising a light-chain CDR1 consisting of an amino acid sequence QNVGGTN (SEQ ID NO: 4), a light-chain CDR2 consisting of an amino acid sequence SAS, and a light-chain CDR3 consisting of an amino acid sequence QQYYIYPYT (SEQ ID NO: 5), the light-chain variable region optionally having 3 or fewer amino acid substitutions; a recombinant virus comprising RNA encoded by the bornavirus vector; a cell infected with the recombinant virus; and a pharmaceutical composition comprising the cell.