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1.发明公开
公开(公告)号：EP1666486A1
公开(公告)日：2006-06-07
申请号：EP04772926.4
申请日：2004-09-03
发明人： NEMOTO, H. Graduate School of Pharmaceutical Sce. , YAMAUCHI,M. Pharma.Rsrch Ctr. Kyowa Hakko Kogyo Co , KUSANO, H. Pharma. Res. Ctr Kyowa Hakko Kogyo Co. , KATO, Yasuki Pharma. Res. Ctr Kyowa Hakko Kogyo Co , YAMASAKI, M. Tokyo Res. Labs. Kyowa Hakko Kogyo Co , SUZAWA, T. Head Office Kyowa Hakko Kogyo Co., Ltd.
IPC分类号： C07K5/08 , C07C233/47 , C07C323/52 , C07D207/404 , A61K9/107 , A61K9/127 , A61K47/42
CPC分类号： C07D207/452 , A61K47/00 , A61K47/54 , A61K47/6911 , B82Y5/00 , C07C323/60 , C07F9/10 , C07K5/0202
摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1):
wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R-X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number:
directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.摘要翻译： 本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含它的细颗粒; 等等。 本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基 包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质 和疏水性物质，至RX或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或通过间隔基或其盐具有n数的以下结构的残基： 包含它的细颗粒; 等等。
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