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公开(公告)号：EP3656791A1
公开(公告)日：2020-05-27
申请号：EP18836123.2
申请日：2018-07-18
发明人： KAI, Masayuki , OGAWA, Shinya , TAKETO, Makoto , KAWADA, Kenji , HIRAI, Hideyo , SAKAI, Yoshiharu , MAEKAWA, Taira
IPC分类号： C07K16/28 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/12 , C12N15/13 , C12P21/08 , G01N33/53
摘要： An object of the present invention is to provide a monoclonal antibody which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment there of. The present invention relates to a monoclonal antibody which binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15), or an antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment.
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公开(公告)号：EP3168233A3
公开(公告)日：2017-07-26
申请号：EP16204647.8
申请日：2014-05-15
申请人： Kyoto University
IPC分类号： C07K16/18 , A61K31/506 , C07K16/40 , C07K16/30
CPC分类号： G01N33/57496 , A61K31/506 , C07K16/18 , C07K16/30 , C07K16/3046 , C07K16/40 , C07K2317/34 , G01N33/57446 , G01N2333/91205 , G01N2440/14
摘要： The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.
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公开(公告)号：EP3168233A2
公开(公告)日：2017-05-17
申请号：EP16204647.8
申请日：2014-05-15
申请人： Kyoto University
IPC分类号： C07K16/18 , A61K31/506 , C07K16/40 , C07K16/30
CPC分类号： G01N33/57496 , A61K31/506 , C07K16/18 , C07K16/30 , C07K16/3046 , C07K16/40 , C07K2317/34 , G01N33/57446 , G01N2333/91205 , G01N2440/14
摘要： The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.
摘要翻译： 本发明涉及用于确定受试者中癌症预后的方法，该方法包括检测从受试者获得的样品中TRIO 2681位酪氨酸残基的磷酸化的步骤。
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公开(公告)号：EP2997378B1
公开(公告)日：2018-08-08
申请号：EP14798641.8
申请日：2014-05-15
申请人： Kyoto University
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57496 , A61K31/506 , C07K16/18 , C07K16/30 , C07K16/3046 , C07K16/40 , C07K2317/34 , G01N33/57446 , G01N2333/91205 , G01N2440/14
摘要： The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.
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公开(公告)号：EP2997378A1
公开(公告)日：2016-03-23
申请号：EP14798641.8
申请日：2014-05-15
申请人： Kyoto University
IPC分类号： G01N33/574
CPC分类号： G01N33/57496 , A61K31/506 , C07K16/18 , C07K16/30 , C07K16/3046 , C07K16/40 , C07K2317/34 , G01N33/57446 , G01N2333/91205 , G01N2440/14
摘要： The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.
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