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公开(公告)号：EP4365288A1
公开(公告)日：2024-05-08
申请号：EP22833314.2
申请日：2022-06-30
申请人： Kyowa Kirin Co., Ltd. , National University Corporation Tokai National Higher Education and Research System
发明人： IWAI, Hiroto , HOMMA, Masakazu , ATAGO, Takayuki , YAMAMOTO, Junichiro , ABE, Hiroshi , KIMURA, Yasuaki
IPC分类号： C12N15/11 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C12N5/10 , C12N15/67 , C12P21/02
CPC分类号： A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C12N5/10 , C12N15/67 , C12N15/11 , C12P21/02
摘要： The present invention relates to a polynucleotide, containing a translated region from a start codon to a stop codon, a 5' untranslated region, and a poly A chain, in which 65% or more of nucleotides contained in the poly A chain are sugar modified nucleotides.
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公开(公告)号：EP4306118A1
公开(公告)日：2024-01-17
申请号：EP22767136.9
申请日：2022-03-08
发明人： ISHIKAWA Dai , KOIZUMI Satoshi , YAMASHITA Makoto , YAMAZAKI Fuhito , HAYASHI Mikiro , HONMA Nakayuki , URAKAWA Itaru , IWAMOTO Susumu
IPC分类号： A61K35/74 , A23L33/135 , A61P1/04 , A61P3/10 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C12N1/20
摘要： The present invention relates to a composition which contains an intestinal bacterium belonging to Bacteroidetes and having an inflammation reducing activity, or a substance derived from the intestinal bacterium and having an inflammation reducing activity and which has at least one activity selected from an anti-inflammatory activity, an immunoregulation activity, an epithelial barrier restoring activity, an IL-10-inducing activity, and an IL-22-inducing activity, and to an ameliorating agent for an inflammatory disease, an autoimmune disease, or an infectious disease containing the intestinal bacterium and the substance derived from the intestinal bacterium and having an inflammation reducing activity.
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公开(公告)号：EP4219557A1
公开(公告)日：2023-08-02
申请号：EP22211094.2
申请日：2006-11-27
摘要： The invention provides antibodies that specifically bind to OX40 (CD 134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.
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公开(公告)号：EP4130270A1
公开(公告)日：2023-02-08
申请号：EP21782017.4
申请日：2021-04-01
发明人： NIWA Rinpei , USAMI Katsuaki
IPC分类号： C12N15/13 , A61K39/395 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K16/00 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63
摘要： An object of the present invention is to provide an antibody composition, which exhibits an effector function more specifically for a target cell coexpressing two types of antigens that are different from each other and damages the target cell, and also can maintain affinity for the individual target antigens sufficiently high. The present invention relates to an antibody composition against a first antigen and a second antigen that are different from each other, including a first IgG half-molecule and a second IgG half-molecule, and relates to the first IgG half-molecule and the second IgG half-molecule constituting the antibody composition.
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公开(公告)号：EP4105330A1
公开(公告)日：2022-12-21
申请号：EP21753218.3
申请日：2021-02-12
发明人： NIWA Rinpei , OGAWA Shinya , WAJIMA Mami , KUBOTA Tsuguo
IPC分类号： C12N15/13 , A61K39/395 , A61P35/00 , C07K16/18 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/08 , G01N33/574
摘要： An object of the present invention is to provide a bispecific antibody that binds to CD3 or a bispecific antibody fragment thereof. The present invention relates to a bispecific antibody that binds to CD3 or a bispecific antibody fragment thereof, a DNA encoding the bispecific antibody or the bispecific antibody fragment thereof, a vector containing the DNA, a hybridoma and a transformant that produce the bispecific antibody or the bispecific antibody fragment thereof, a method for producing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic agents containing the bispecific antibody or the bispecific antibody fragment thereof, therapeutic and diagnostic methods using the bispecific antibody or the bispecific antibody fragment thereof, and a reagent for detection or measurement containing the bispecific antibody or the bispecific antibody fragment thereof.
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公开(公告)号：EP4056232A1
公开(公告)日：2022-09-14
申请号：EP20864177.9
申请日：2020-09-11
发明人： KANAI Akiko , HOSOMI Hitomi , YONEZAWA Sakiko
IPC分类号： A61P29/00 , A61P37/06 , A61P37/08 , C07K14/715 , C07K16/00 , C07K19/00 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , A61K38/16 , C12P21/02
摘要： An object of the present invention is to provide a DcR3 variant that has binding activity (preferably neutralizing activity) to a ligand of DcR3, and that results in a decreased amount of aggregates as compared to wild-type DcR3 when produced using a cell derived from a mammal as a host, and/or that exhibits improved in vivo kinetics; a DNA encoding the DcR3 variant; a vector including the DNA; a transformant obtained by introducing the vector; a method for producing a variant using the transformant; and a prophylactic or therapeutic agent for an autoimmune disease, an inflammatory disease or an allergic disease including the variant as an active ingredient, and, in order to achieve the object, the present invention provides a DcR3 variant including a part of DcR3 and a part of a TNF superfamily molecule.
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公开(公告)号：EP4039333A1
公开(公告)日：2022-08-10
申请号：EP20873126.5
申请日：2020-09-30
发明人： YAMAMOTO Keisuke , KANAI Toshimi , YOSHIDA Kei , IMAEDA Takashi , ESAKI Masahiro
IPC分类号： A61P35/00 , A61P43/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14 , C07D215/46 , C07D487/04 , C07D487/08 , C07D519/00 , C12N15/09 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/551
摘要： The present invention provides a BET (protein) degrader, specifically a BET degrader containing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof:
wherein L1 and L2 are the same or different and each represents a small molecular ligand for BET protein, and S represents a group represented by a formula selected from the group consisting of formulas (SI) to (S18).-
公开(公告)号：EP4006047A1
公开(公告)日：2022-06-01
申请号：EP20846472.7
申请日：2020-07-29
摘要： The purpose of the present invention is to provide: a method for purifying an antibody in non-adsorption mode using an inorganic compound that contains silicon dioxide and aluminum oxide, as a method for producing an antibody at a lower cost than the prior art; a method for producing an antibody that includes the purification method; and an antibody, etc., produced by the production method. The present invention pertains to a method for purifying an antibody in non-adsorption mode using an inorganic compound that contains silicon dioxide and aluminum oxide, a method for producing an antibody that includes the purification method, and an antibody produced by the production method.
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公开(公告)号：EP3858994A1
公开(公告)日：2021-08-04
申请号：EP19867148.9
申请日：2019-09-27
发明人： NIWA, Rinpei , USAMI, Katsuaki
IPC分类号： C12N15/13 , A61K39/395 , A61P43/00 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/08
摘要： An object of the present invention is to provide an antibody composition, which more selectively exhibits an effector function against a target cell coexpressing two types of antigens that are different from each other and damages the target cell, and also can maintain affinity for the individual target antigens sufficiently high. The present invention relates to an antibody composition against a first antigen and a second antigen that are different from each other, composed of a first IgG half-molecule and a second IgG half-molecule.
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公开(公告)号：EP3712129A1
公开(公告)日：2020-09-23
申请号：EP18819602.6
申请日：2018-06-22
发明人： DANJO Tomohiro , YAMADA Hiroki , NAKAJIMA Takahiro
IPC分类号： C07D213/75 , C07D215/20 , A61K31/335 , C07D215/26
摘要： An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like:
[wherein, "A" represents optionally substituted heterocyclic diyl,
R 1 represents hydrogen atom or optionally substituted lower alkyl,
R 2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group,
X represents -O-, -S-, -SO 2 -, -NR X1 - (wherein, R X1 represents hydrogen atom or lower alkyl), -CHR X2 - (wherein, R X2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and
n1 and n2 are the same or different, and each represents 0 or 1].
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