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    PROTEIN SKELETAL MODULE WHICH INCREASES THE BINDING AFFINITY AND BINDING SPECIFICITY OF ACTIVE POLYPEPTIDES
    2.
    发明公开
    PROTEIN SKELETAL MODULE WHICH INCREASES THE BINDING AFFINITY AND BINDING SPECIFICITY OF ACTIVE POLYPEPTIDES 有权
    蛋白骨架模块以增加亲和力和结合活性多肽的结合特异性

    公开(公告)号：EP2700649A2

    公开(公告)日：2014-02-26

    申请号：EP12773577.7

    申请日：2012-04-18

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： CHA, Kiweon ,  SO, In-Seop ,  KIM, Soyoun ,  LEE, Byung-Heon ,  KIM, In San

    IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/68

    CPC分类号： C07K14/485 ,  C07K14/47 ,  C07K14/5406 ,  C07K14/705 ,  C07K2319/00 ,  G01N33/68

    摘要： The present invention relates to a novel protein skeletal module which increases the binding affinity or binding specificity of active polypeptides. More particularly, the present invention relates to a protein skeletal module comprising polypeptides consisting of the 1 st to 19 th amino acids of the amino acid sequence expressed in sequence number 1; polypeptides comprising active polypeptides; and polypeptides consisting of the 29 th to 86 th amino acids of the amino acid sequence expressed in sequence ID number 1. The present invention also relates to a method for preparing the protein skeletal module. The protein skeletal module of the present invention increases the binding affinity or binding specificity of active polypeptides embedded therein, and therefore is effective in diagnosing and treating diseases.

    摘要翻译： 本发明涉及一种新的蛋白质骨架模块，这增加了结合亲和力或活性的多肽的结合特异性。 更具体地，本发明涉及一种蛋白质骨架模块包括多肽，其由第1至第19中的序列号1中过表达的氨基酸序列的氨基酸; 多肽，其包含的活性多肽; 第29届的和多肽，其由以第86次在序列ID号1中。因此，本发明涉及一种用于制备所述蛋白质骨架模块中过表达的氨基酸序列的氨基酸。 本发明的蛋白质骨架模块增大嵌入其中活性多肽的结合亲和力或结合特异性，并因此能有效地诊断和治疗疾病。