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1.发明公开NUCLEAR DNA CONTENT OF CHO CELL LINES AS A SELECTION CRITERION IN SCREENING OF THE BEST RECOMBINANT PROTEIN PRODUCERS 有权CHO细胞系，为选择标准核DNA含量WHILE筛选最佳重组蛋白PRODUCER
公开(公告)号：EP2638146A1
公开(公告)日：2013-09-18
申请号：EP11779450.3
申请日：2011-11-09
发明人： OBRSTAR, Darja
摘要： The present invention relates to a method for selecting for cells or cell lines that produce a recombinant protein/polypeptide in high yields, the method allowing for the selection of high producer cells or cell lines in an early phase of cell line development, the method comprising the step of determining the nuclear DNA content of the cells or cell lines, wherein the level of the nuclear DNA content of the cells or cell lines positively correlates with the capacity of the cells or cell lines to produce the recombinant protein/polypeptide.
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2.发明授权NUCLEAR DNA CONTENT OF CHO CELL LINES AS A SELECTION CRITERION IN SCREENING OF THE BEST RECOMBINANT PROTEIN PRODUCERS 有权CHO细胞系，为选择标准核DNA含量WHILE筛选最佳重组蛋白PRODUCER
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