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    CROSSLINKED AMIDE DERIVATIVES OF HYALURONIC ACID AND MANUFACTURING METHOD THEREOF
    1.
    发明公开
    CROSSLINKED AMIDE DERIVATIVES OF HYALURONIC ACID AND MANUFACTURING METHOD THEREOF 有权
    透明质酸的交联酰胺衍生物及其制造方法

    公开(公告)号：EP1328552A1

    公开(公告)日：2003-07-23

    申请号：EP01974948.0

    申请日：2001-10-10

    申请人： LG Life Sciences Ltd.

    发明人： MOON, Tae-Seok ,  LEE, Jae-Young ,  KIM, Jin-Hoon ,  HAN, Kyu-Boem

    IPC分类号： C08B37/08

    CPC分类号： C08B37/0072 ,  A61L27/20 ,  A61L31/042 ,  C08L5/08

    摘要： The present invention relates to water-insoluble, crosslinked amide derivatives of hyaluronic acid and manufacturing method thereof, where the amide derivatives of hyaluronic acid are characterized by crosslinking, of polymer or oligomer having two or more amine groups, with hyaluronic acid or its hyaluronate salts through amidation reaction.The water-insoluble, crosslinked amide derivatives of hyaluronic acid according to the present invention may be diversely used for prevention of adhesion after surgical operation, correction of facial wrinkles, dermal augmentation, tissue engineering, osteoarthritic viscosupplement etc.