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1.发明授权
公开(公告)号：EP4063433B1
公开(公告)日：2024-09-04
申请号：EP20888940.2
申请日：2020-03-18
IPC分类号： C08B37/08 , C08F8/14 , C08F8/34 , C08H1/06 , C08L89/06 , C08B37/00 , C08L51/02 , C08L5/08 , C08F289/00 , C08F265/06 , C08F261/04 , C08J3/075 , C08G65/334 , C08F251/00 , A61L31/14 , A61L27/52
CPC分类号： A61L27/52 , C08F251/00 , C08F265/06 , C08F261/04 , C08F289/00 , C08J3/075 , C08L5/08 , C08L51/02 , C08G65/3344 , A61L31/145 , C08L89/06 , C08B37/0072 , C08B37/0069 , C08H1/06 , C08B37/003 , C08F8/14 , C08F8/34 , C08J2351/0220130101 , C08J2305/0820130101 , C08J2389/0620130101 , C08J2489/0620130101 , C08J2405/0820130101
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2.发明公开
公开(公告)号：EP4360665A3
公开(公告)日：2024-07-10
申请号：EP24162602.7
申请日：2020-08-14
申请人： Axogen Corporation
发明人： DEISTER, Curt
CPC分类号： A61L27/34 , A61L27/3629 , A61L27/3695 , A61L2430/3220130101 , C08L5/04 , C08B37/0084 , C08B37/0072 , A61L2400/1020130101
摘要： Provided herein is a tissue repair membrane with a hydrogel polymer. The tissue repair membrane can provide adhesion and/or lubrication to assist with the use and implantation of the tissue repair membrane, and to facilitate healing and/or avoid or minimize damage to adjacent, e.g., tissues, during or after implantation.
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3.发明公开
公开(公告)号：EP4356937A3
公开(公告)日：2024-07-10
申请号：EP24162609.2
申请日：2020-08-14
申请人： Axogen Corporation
发明人： DEISTER, Curt
CPC分类号： A61L27/34 , A61L27/3629 , A61L27/3695 , A61L2430/3220130101 , C08L5/04 , C08B37/0084 , C08B37/0072 , A61L2400/1020130101
摘要： Provided herein is a tissue repair membrane with a hydrogel polymer. The tissue repair membrane can provide adhesion and/or lubrication to assist with the use and implantation of the tissue repair membrane, and to facilitate healing and/or avoid or minimize damage to adjacent, e.g., tissues, during or after implantation.
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4.发明公开
公开(公告)号：EP4356937A2
公开(公告)日：2024-04-24
申请号：EP24162609.2
申请日：2020-08-14
申请人： Axogen Corporation
发明人： DEISTER, Curt
IPC分类号： A61L27/38
CPC分类号： A61L27/34 , A61L27/3629 , A61L27/3695 , A61L2430/3220130101 , C08L5/04 , C08B37/0084 , C08B37/0072 , A61L2400/1020130101
摘要： Provided herein is a tissue repair membrane with a hydrogel polymer. The tissue repair membrane can provide adhesion and/or lubrication to assist with the use and implantation of the tissue repair membrane, and to facilitate healing and/or avoid or minimize damage to adjacent, e.g., tissues, during or after implantation.
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公开(公告)号：EP2485880B1
公开(公告)日：2018-12-26
申请号：EP10821626.8
申请日：2010-10-08
申请人： UPM Plywood Oy
发明人： KILJUNEN, Samantha , KOSKI, Anna , KUNTTU, Mika , VALKONEN, Tiina
CPC分类号： B27K3/08 , B27K3/15 , C08B15/10 , C08B31/003 , C08B37/003 , C08B37/0045 , C08B37/0057 , C08B37/0072 , C08B37/0084 , C08H1/00 , C08H6/00 , C08H8/00 , C08L5/08 , C08L97/02 , C08L5/00 , C08L1/02 , C08L3/02
摘要： The invention relates to a method for impregnating chemicals into wood. In accordance with the invention, the chemicals include a cross-linking agent having carboxyl groups and a low molecular weight oligomer having reactive -OH groups, the cross-linking agent being reactive with -OH groups of the wood and the low molecular weight oligomer; and the chemicals are impregnated into the wood cell wall and the carboxyl groups of the cross-linking agent form ester cross- linking bonds with -OH groups of the wood and/or low molecular weight oligomer in the wood cell wall for improving dimensional stability of the wood product.
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公开(公告)号：EP2783702B1
公开(公告)日：2018-11-14
申请号：EP12851320.7
申请日：2012-11-21
发明人： AH, Young Chang , CHO, Sung Yeon , HWANG, In Seok , PARK, Sun Young , KO, Hyun Ju , KIM, Hyuk , KWON, Min Jung , PARK, Won Seok
CPC分类号： C08L5/08 , A61K9/06 , A61K47/36 , A61L15/28 , A61L27/20 , A61L2400/06 , C08B37/0072
摘要： The invention, provides a method for preparing a water insoluble gel composition comprising: mixing a water soluble an epoxy cross-linking agent, an alkaline compound and a solvent; and drying the thus mixture at 1 to 30°C under vacuum to remove the solvent, and a water insoluble gel composition.
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公开(公告)号：EP2688402B1
公开(公告)日：2018-10-24
申请号：EP12761460.0
申请日：2012-03-23
IPC分类号： A61K31/737 , A61K45/06 , A61P13/00 , A61P29/00
CPC分类号： A61K31/737 , A23L2/38 , A23L2/52 , A23V2002/00 , A61K9/0034 , A61K31/728 , A61K45/06 , C08B37/0072 , A61K2300/00
摘要： Described herein are methods for treating or preventing urological inflammation in a subject comprising administering to the subject an effective amount of a compound comprising a. a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an alkyl group or fluoroalkyl group; b. a partially or fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof, or a combination thereof.
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公开(公告)号：EP3241852B1
公开(公告)日：2018-10-17
申请号：EP16734888.7
申请日：2016-01-04
发明人： ZHONG, Zhiyuan , ZHONG, Yinan , MENG, Fenghua , YUAN, Jiandong , HUANG, Yangqing , CHI, Jianwen
CPC分类号： A61K9/5161 , A61K9/51 , A61K31/704 , A61K31/728 , A61K31/795 , A61K47/183 , A61K47/20 , A61K47/36 , C08B37/0072
摘要： Disclosed are a hyaluronic acid-based amphiphilic polymer, preparation method and application thereof. A main chain of the amphiphilic polymer is a hydrophilic hyaluronic acid and can be employed in active targeting, and a side chain thereof is a hydrophobic group represented by Formula (1). The amphiphilic polymer can carry a small molecule anticancer drug. Polymer nanoparticles are obtained via chemical crosslinking, such that the nanoparticles are not readily dissociated outside a cell or in blood, thus ensuring the stability of a drug encapsulated by the nanoparticles. Upon arriving at a tumor tissue, the hyaluronic acid on a surface of the nanoparticle can immediately combine with a CD44 receptor on a surface of a tumor cell, and effectively enter the tumor cell via endocytosis mediated by the receptor, and then quickly de-crosslink to be dissociated. The drug is quickly released, obtaining an enrichment ratio at a tumor site markedly higher than that of the prior art, resulting in a highly effective treatment, and addressing deficiencies such as drug leakage, low carrying efficiency, low occurrence of endocytosis and slow release in a cell.
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公开(公告)号：EP3063177B1
公开(公告)日：2018-08-15
申请号：EP14798720.0
申请日：2014-10-23
IPC分类号： C08B37/00 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/737 , C08B37/08
CPC分类号： C08B37/0075 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/737 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0078
摘要： The invention relates to N-desulfated and optionally 2-O-desulfated glycosaminoglycan derivatives, wherein at least part of the adjacent diols and OH/NH 2 have been converted into the corresponding aldehyde, which aldehydes have been then reduced to the corresponding alcohol. These products are endowed with heparanase inhibitory activity and anti-tumor activity. Said glycosaminoglycan derivatives are obtained from natural or synthetic glycosaminoglycan, preferably from unfractionated heparin, low molecular weight heparins (LMWHs), heparan sulfate or derivatives thereof. The invention further relates to the process for preparation of the same and further to their use as active ingredients of medicaments, also in combination with known established drugs or treatments. The present invention further relates to a process for breaking the C 2 -C 3 linkage of glycosamine residues of a glycosaminoglycan by oxidation of said glycosaminoglycan.
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公开(公告)号：EP2753647B1
公开(公告)日：2018-08-15
申请号：EP12772834.3
申请日：2012-09-06
申请人： ALLERGAN, INC.
CPC分类号： A61L27/24 , A61K8/042 , A61K8/65 , A61K8/735 , A61K2800/91 , A61L27/26 , A61L27/52 , A61L2400/06 , A61L2430/34 , A61Q19/08 , C08B37/0072 , C08H1/00 , C08L5/08 , C08L89/00 , H04R1/1066 , H04R1/1075 , C08L5/00 , C08L89/06
摘要： Hyaluronic acid and collagen may be crosslinked in aqueous solution as described herein. The crosslinked macromolecular matrices obtained in this process may be used as a hydrogel for implants and fillers for human aesthetic and therapeutic products.
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