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公开(公告)号:EP1317542A2
公开(公告)日:2003-06-11
申请号:EP01982261.8
申请日:2001-09-07
申请人: LION Bioscience AG
发明人: CASARI, Georg , HÖFER, Michael , JACKSON, David , KRANZ, Harald , OTTE, Kerstin , REMMEL, Bettina , SUCKOW, Jörg
IPC分类号: C12N15/12 , C07K14/705 , C12N5/10 , G01N33/68 , C07K16/28 , C12Q1/68 , C12N15/11 , A61K48/00 , A61K39/395 , A61K31/7088
CPC分类号: C07K14/70567 , A61K38/00 , A61K48/00
摘要: The present invention relates to a novel nuclear receptor called 'L66' or also FXR-β a homologue of the FXR-α, a prototypical type 2 nuclear receptor. The invention also relates to the isolated nucleic acid sequence of L66 and the isolated protein thereof. The invention further relates to processes for isolating and/or producing the nucleic acid or the protein as well as methods of use of the receptor L66.
摘要翻译: 本发明涉及称为'L66'的新型核受体或FXR-α(原型2型核受体)的同系物FXR-β。 本发明还涉及L66的分离的核酸序列及其分离的蛋白质。 本发明还涉及用于分离和/或生产核酸或蛋白质的方法以及受体L66的使用方法。