利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.014 秒)

    DETECTION METHOD FOR NOVEL ROS1 FUSION PRODUCT
    3.
    发明公开
    DETECTION METHOD FOR NOVEL ROS1 FUSION PRODUCT 有权
    VERFAHREN ZUM NACHWEIS EINES NEUEN ROS1-FUSIONSPRODUKTS

    公开(公告)号：EP2586862A1

    公开(公告)日：2013-05-01

    申请号：EP11798177.9

    申请日：2011-06-22

    申请人： Astellas Pharma Inc. ,  Japanese Foundation For Cancer Research ,  Educational Foundation Jichi Medical University

    发明人： TAKEUCHI Kengo ,  ISHIKAWA Yuichi ,  MANO Hiroyuki ,  SODA Manabu ,  SAI Eirin

    IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C12Q1/6886 ,  C12P19/34 ,  C12Q1/68 ,  C12Q2600/156 ,  G01N33/57484

    摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

    摘要翻译： 阐明了作为癌症的新的致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因的一部分和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。