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22 条记录 (耗时 0.024 秒)

    DETECTION METHOD FOR NOVEL ROS1 FUSION PRODUCT
    3.
    发明公开
    DETECTION METHOD FOR NOVEL ROS1 FUSION PRODUCT 有权
    VERFAHREN ZUM NACHWEIS EINES NEUEN ROS1-FUSIONSPRODUKTS

    公开(公告)号：EP2586862A1

    公开(公告)日：2013-05-01

    申请号：EP11798177.9

    申请日：2011-06-22

    申请人： Astellas Pharma Inc. ,  Japanese Foundation For Cancer Research ,  Educational Foundation Jichi Medical University

    发明人： TAKEUCHI Kengo ,  ISHIKAWA Yuichi ,  MANO Hiroyuki ,  SODA Manabu ,  SAI Eirin

    IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C12Q1/6886 ,  C12P19/34 ,  C12Q1/68 ,  C12Q2600/156 ,  G01N33/57484

    摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

    摘要翻译： 阐明了作为癌症的新的致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因的一部分和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。

    SURGICAL SYSTEM FOR STOMA CLOSURE IN BIOLOGICAL DUCT
    6.
    发明授权
    SURGICAL SYSTEM FOR STOMA CLOSURE IN BIOLOGICAL DUCT 有权
    生物流体中的肛门闭合手术系统

    公开(公告)号：EP2452631B1

    公开(公告)日：2018-03-07

    申请号：EP10797213.5

    申请日：2010-07-12

    申请人： Educational Foundation Jichi Medical University

    发明人： OHDAIRA, Takeshi

    IPC分类号： A61B17/04 ,  A61B17/00 ,  A61B17/064 ,  A61B17/068

    CPC分类号： A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/068 ,  A61B2017/00544 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0427 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0496 ,  A61B2017/0647

    摘要： Disclosed is a surgical system for small-pit closure in hollow organs having excellent operability, safety, and reliability, and whereby it is possible to reduce the duration and invasiveness of surgery by avoiding major surgical procedures. The surgical system is provided with a surgical device (1, 1A) for small-pit closure in hollow organs, with said surgical device including the following components, which are connected sequentially: a suture-member cartridge (5-5B) in which a pair of parallel tubular members (51) that accommodate respective suture members (100-120) configured of a suture thread (103-143) are feedably connected to the rear ends of a pair of arrowy-shaped members (101-121) that latch into tissue in a hollow organ; an auxiliary shooting unit (3-3B) having plungers respectively provided in a pair of cylinders (31, 31B) open at both ends; a hollow-organ-insertable unit (2, 2A) configured of a pair of flexible air tubes; and a gas shooter (4-4B) that sequentially discharges compressed air or high-pressure gas into the open-ended cylinders in response to operations of a trigger (44-4B4), for sequentially ejecting the arrowy-shaped members and driving the same into tissue in the hollow organ (T) on both sides of a small pit (Tc) site. The surgical device is used, in combination with an endoscope (200, 200A) that is inserted into the hollow organ, for closing and suturing the hollow organ tissue at the small-pit site.

    SURGICAL SYSTEM AND SURGICAL METHOD FOR NATURAL ORIFICE TRANSLUMINAL ENDOSCOPIC SURGERY (NOTES)
    8.
    发明公开
    SURGICAL SYSTEM AND SURGICAL METHOD FOR NATURAL ORIFICE TRANSLUMINAL ENDOSCOPIC SURGERY (NOTES) 有权
    手术器官手术（自然手术透视内镜手术）

    公开(公告)号：EP2283784A1

    公开(公告)日：2011-02-16

    申请号：EP09738812.8

    申请日：2009-04-28

    申请人： Educational Foundation Jichi Medical University

    发明人： OHDAIRA, Takeshi

    IPC分类号： A61B17/115 ,  A61B17/072

    CPC分类号： A61B17/07207 ,  A61B17/115

    摘要： Provide a system and method for use in NOTES so as to reduce surgical invasiveness. An insertion body that is connected by an anvil assembly and joined to a thin wire guide (electric guide wire), is inserted via a natural orifice into a hollow organ so as to incise and remove a diseased or defective site from the hollow organ by using a pair of (front-end/rear-end) linear cutters of a linear cutting/stapling device (linear stapler), after which the two cut ends of the tract are anastomosed and recovered by a circular anastomosis surgical stapler that is equipped with the system.

    摘要翻译： 提供在NOTES中使用的系统和方法，以减少手术侵袭。 通过砧组件连接并连接到细导线（电导线）的插入体经由天然孔插入中空器官中，以便通过使用中空器官切割并去除中空器官的病变或缺陷部位 线性切割/缝合装置（线性吻合器）的一对（前端/后端）线性切割器，之后，通过圆形吻合手术吻合器将道的两个切割端吻合并回收，该吻合器装备有 系统。

    NOVEL TESTING METHOD AND TESTING REAGENT FOR ANGIITIS
    10.
    发明公开
    NOVEL TESTING METHOD AND TESTING REAGENT FOR ANGIITIS 有权
    除了TESTVERFAHRENFÜRANGIITIS

    公开(公告)号：EP2620770A1

    公开(公告)日：2013-07-31

    申请号：EP11826607.1

    申请日：2011-05-12

    申请人： National University Corporation Chiba University ,  Educational Foundation Jichi Medical University

    发明人： SUZUKI, Kazuo ,  NAKAYAMA, Toshinori ,  NAKAJIMA, Hiroshi ,  NAGAO, Tomokazu ,  YUMURA, Wako

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6854 ,  G01N33/564 ,  G01N2800/328

    摘要： [Problem] The present invention provides a novel pathological marker of angiitis which serves as an alternative to MPO-ANCAs. [Means for Solution]According to one embodiment of the present invention, a method for testing angiitis which includes a step of detecting an antibody specifically recognizing a moesin in a biological sample is provided. In addition, according to another embodiment of the present invention, a reagent for testing angiitis which contains a substance that detects an antibody specifically recognizing a moesin in a biological sample is provided.

    摘要翻译： [问题]本发明提供了作为MPO-ANCA的替代物的血管炎的新型病理学标志物。 [解决方案]根据本发明的一个实施方案，提供了一种检测血管炎的方法，其包括检测特异性识别生物样品中的moesin的抗体的步骤。 此外，根据本发明的另一个实施方案，提供了一种用于测试血管炎的试剂，其包含检测特异性识别生物样品中的moesin的抗体的物质。