公开(公告)号：EP0850319B1

公开(公告)日：2004-03-24

申请号：EP96930710.7

申请日：1996-09-04

申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH

发明人： VAN DAMME, Jo ,  PROOST, Paul ,  HOUSSIAU, Frederic ,  RENAULD, Jean-Christophe

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  C12N5/00

CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K14/5412

摘要： The invention is based upon the newly recognized ability of beta chemokines to inhibit cell apoptosis. In particular, apoptosis of T cells is described. The known beta chemokines I-309 and TCA-3 are examples of the beta chemokines which inhibit apoptosis. One aspect of the invention is the use of these molecules to inhibit apoptosis. A second aspect of the invention is the use of beta chemokine inhibitors or antagonists to provoke apoptosis.

公开(公告)号：EP0850319A1

公开(公告)日：1998-07-01

申请号：EP96930710.0

申请日：1996-09-04

申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH

发明人： VAN DAMME, Jo ,  PROOST, Paul ,  HOUSSIAU, Frederic ,  RENAULD, Jean-Christophe

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61P9 ,  A61P13 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07K14 ,  C12Q1

CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K14/5412

摘要： The invention is based upon the newly recognized ability of β chemokines to inhibit cell apoptosis. In particular, apoptosis of T cells is described. The known β chemokines I-309 and TCA-3 are examples of the β chemokines which inhibit apoptosis. One aspect of the invention is the use of these molecules to inhibit apoptosis. A second aspect of the invention is the use of β chemokine inhibitors or antagonists to provoke apoptosis.