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1.发明公开ISOLATED NUCLEIC ACID MOLECULE ENCODING PEPTIDES WHICH FORM COMPLEXES WITH MHC MOLECULE HLA-Cw*1601 AND USES THEREOF 失效分离的核酸分子FOR肽编码复合体与MHC分子HLA-CW 1601 * MAKE，其使用
公开(公告)号：EP0811076A1
公开(公告)日：1997-12-10
申请号：EP96904577.0
申请日：1996-02-07
发明人： BOEL, Pascale , WILDMANN, Claude , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , COULIE, Pierre , RENAULD, Jean-Christophe
IPC分类号： C12N15 , A61K35 , A61K38 , A61P35 , A61P37 , C07H21 , C07K7 , C07K14 , C12N1 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/70539 , A61K38/00 , C07K14/4748
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
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2.发明公开METHODS FOR DETECTION AND TREATMENT OF INDIVIDUALS HAVING ABNORMAL CELLS EXPRESSING HLA-A2/TYROSINASE PEPTIDE ANTIGENS 失效方法的检测和治疗具有异常HLA-A2 /酪氨酸酶肽抗原表达细胞的个体
公开(公告)号：EP0687180A1
公开(公告)日：1995-12-20
申请号：EP94905393.0
申请日：1993-12-14
发明人： BOON-FALLEUR, Thierry , BRICHARD, Vincent , VAN PEL, Aline , DE PLAEN, Etienne , COULIE, Pierre , RENAULD, Jean-Christophe , WOLFEL, Thomas , LETHE, Bernard
IPC分类号： C12N15 , A61K35 , A61K38 , A61K49 , A61P43 , C07K7 , C07K14 , C07K16 , C12N5 , C12N9 , C12Q1 , G01N33 , A61K39 , A61K48
CPC分类号： G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/535 , C07K16/243 , C12N9/0071 , C12Y114/18001 , G01N33/505 , Y10S436/813 , Y10S514/885 , Y10S530/828
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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3.发明公开NUCLEIC ACID SEQUENCES CODING FOR OR COMPLEMENTARY TO NUCLEIC ACID SEQUENCES CODING FOR INTERLEUKIN 9 RECEPTOR 失效白介素9受体的核酸序列编码或 ENSURE互补NULEINSÄURESEQUENZEN。
公开(公告)号：EP0643719A1
公开(公告)日：1995-03-22
申请号：EP93907050.0
申请日：1993-02-25
IPC分类号： G01N33 , A61K39 , C07H15 , C07H21 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , A61K38 , C12R1
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155
摘要： The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as agents to transfect recipient cells.
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公开(公告)号：EP1537211A2
公开(公告)日：2005-06-08
申请号：EP02791396.1
申请日：2002-12-09
发明人： RENAULD, Jean-Christophe , FICKENSICHER, H.,Inst. f. Klinische u. Molekulare , DUMOUTIER, Laure , HOR, S.,Inst. f. Klinische und Molekulare
IPC分类号： C12N15/12 , C12N5/10 , C12P21/02 , C07K14/47 , C07K14/705
CPC分类号： C07K14/715 , A61K38/00
摘要： The invention relates to new members of the Class II cytokine receptor family, such as LICR-2. The new member binds to AK155, and mediates STAT activation.
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5.发明公开
公开(公告)号：EP1305419A2
公开(公告)日：2003-05-02
申请号：EP01952260.6
申请日：2001-06-27
CPC分类号： G01N33/6869 , A61K38/00 , C07K14/54 , G01N33/505
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors. The molecules are implicated in activation of STAT molecules, acute phase proteins, and inflammation.
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6.发明公开
公开(公告)号：EP1007093A1
公开(公告)日：2000-06-14
申请号：EP97939680.1
申请日：1997-08-29
CPC分类号： A61K38/206 , A61K38/2026 , Y10S514/813 , Y10S514/86 , Y10S514/885 , A61K38/20 , A61K2300/00
摘要： A method for the treatment and prevention of immune disorders and fibrosis associated disorders is disclosed. The method involves administering interleukin-9 in an effective amount to the subject. Among the conditions treatable are thyroiditis, autoimmune diabetes and silicosis.
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7.发明公开
公开(公告)号：EP3786187A1
公开(公告)日：2021-03-03
申请号：EP20201515.2
申请日：2014-08-01
发明人： LUCAS, Sophie , COULIE, Pierre , CUENDE VILLASUR, Julia , DUMOUTIER, Laure , RENAULD, Jean-Christophe , VAN DER WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Hans , DE BOECK, Gitte
摘要： The present invention relates to a protein binding to GARP in the presence of TGF-β and uses thereof.
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公开(公告)号：EP1499352A1
公开(公告)日：2005-01-26
申请号：EP03746713.1
申请日：2003-04-11
发明人： REED, Jennifer, Lynne , DALL'ACQUA, William , VAN SNICK, Jacques , RENAULD, Jean-Christophe , CORMONT, Francoise , UYTTENHOVE, Catherine
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.
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9.发明授权METHODS FOR DETECTION AND TREATMENT OF INDIVIDUALS HAVING ABNORMAL CELLS EXPRESSING HLA-A2/TYROSINASE PEPTIDE ANTIGENS 失效方法的检测和治疗具有异常HLA-A2 /酪氨酸酶肽抗原表达细胞的个体
公开(公告)号：EP0687180B1
公开(公告)日：2000-11-08
申请号：EP94905393.8
申请日：1993-12-14
发明人： BOON-FALLEUR, Thierry , BRICHARD, Vincent , VAN PEL, Aline , DE PLAEN, Etienne , COULIE, Pierre , RENAULD, Jean-Christophe , WOLFEL, Thomas , LETHE, Bernard
CPC分类号： G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/535 , C07K16/243 , C12N9/0071 , C12Y114/18001 , G01N33/505 , Y10S436/813 , Y10S514/885 , Y10S530/828
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10.发明公开ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开ASTMA相关因子为靶特应性过敏AS ASTMA和相关疾病的治疗
公开(公告)号：EP1015492A2
公开(公告)日：2000-07-05
申请号：EP98948370.6
申请日：1998-09-18
发明人： RENAULD, Jean-Christophe , LOUAHED, Jamila , GRASSO, Luigi , LEVITT, Roy , NICOLAIDES, Nicholas
CPC分类号： C07K14/4718 , A61K38/00 , G01N33/57484
摘要： A new gene in the Ras family that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and certain lymphomas or leukemias. A method for the identification and use of small molecule inhibitors of Ras to treat these disorders. A method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders and certain lymphomas and leukemias by measuring the level of Ras in biologic samples using antibody specific for the Ras protein.
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