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1.发明授权ISOLATED PEPTIDES DERIVED FROM MAGE TUMOR REJECTION ANTIGEN PRECURSORS WHICH COMPLEX WITH HLA-A2 MOLECULES 失效衍生自与HLA-A2分子复合的肿瘤抑制性抗原前体的分离肽
公开(公告)号：EP0804483B1
公开(公告)日：2000-12-27
申请号：EP95914838.8
申请日：1995-03-22
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , RIJKSUNIVERSITEIT LEIDEN
发明人： TOWNSEND, Alan Molecular Immunology Group , BASTIN, Judy Molecular Immunology Group , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierrce , COULIE, Pierre , GAJEWSKI, Thomas , MELIEF, Cornelis J.M. , VISSEREN, M.W. , KAST, W.M.
IPC分类号： C07K14/705 , C12N5/06 , C07K16/28 , A61K38/16 , G01N33/576
CPC分类号： C07K14/4748 , A61K38/00
摘要： Tumor rejection antigens derived from MAGE tumor rejection precursors have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
摘要翻译： 已经鉴定出来自MAGE肿瘤排斥前体的肿瘤排斥抗原。 这些“TRAS”与MHC-I类分子HLA-A2结合，所产生的复合物刺激裂解呈递细胞的溶细胞T细胞克隆的产生。 肽和复合物可以在诊断上，治疗上以及用于产生抗体的免疫原或用作产生溶细胞T细胞克隆的靶标。
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2.发明公开ISOLATED PEPTIDES DERIVED FROM MAGE TUMOR REJECTION ANTIGEN PRECURSORS WHICH COMPLEX WITH HLA-A2 MOLECULES 失效衍生自与HLA-A2分子复合的肿瘤抑制性抗原前体的分离肽
公开(公告)号：EP0804483A1
公开(公告)日：1997-11-05
申请号：EP95914838.0
申请日：1995-03-22
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , RIJKSUNIVERSITEIT LEIDEN
发明人： TOWNSEND, Alan Molecular Immunology Group , BASTIN, Judy Molecular Immunology Group , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierrce , COULIE, Pierre , GAJEWSKI, Thomas , MELIEF, Cornelis J.M. , VISSEREN, M.W. , KAST, W.M.
IPC分类号： G01N33 , A61K35 , A61K38 , A61K39 , A61P35 , A61P37 , C07K7 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21
CPC分类号： C07K14/4748 , A61K38/00
摘要： Tumor rejection antigens derived from MAGE tumor rejection precursors have been identified. These 'TRAS' bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
摘要翻译： 已经鉴定出来自MAGE肿瘤排斥前体的肿瘤排斥抗原。 这些'TRAS'与MHC I类分子HLA-A2结合，并且所得到的复合物刺激裂解呈递细胞的溶细胞T细胞克隆的产生。 肽和复合物可以在诊断上，治疗上以及用于产生抗体的免疫原或用作产生溶细胞T细胞克隆的靶标。
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