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1.发明公开
公开(公告)号：EP3117867A1
公开(公告)日：2017-01-18
申请号：EP14885596.8
申请日：2014-03-12
发明人： TAKADA, Kanji , ONO, Ichiro
CPC分类号： A61M37/0015 , A61K9/0014 , A61K38/00 , A61K38/1825 , A61M2037/0023 , A61M2037/0046 , A61M2202/07 , A61M2202/097
摘要： The problem of the invention is to provide a microneedle preparation administration apparatus that prevents overdosing caused by duplicate administration within a treatment range of skin, more reliably administers a prescribed dose of a growth factor at an intended optional depth in the dermis, exhibits an intended effect, and avoids pigmentation side effects. The solution to the problem is a microneedle preparation administration apparatus comprising: a guide tube; a pedestal in which at least a part thereof including a front end surface is housed within the guide tube and slides in length direction; and driving means for driving the pedestal toward a front end part of the guide tube, and microneedle preparations being to be attached to the front end surface of the pedestal, and the microneedle preparations being to be pressed out from a front end part of the guide tube, wherein the microneedle preparation has a first portion having a tip end part and containing an objective substance, and a second portion having a bottom part and not containing the objective substance, and the front end surface of the pedestal is struck on skin at a collision pressure of 30 N to 200 N per 1 cm 2 .
摘要翻译： 该发明的问题是提供一种微针制备给药装置并防止过量给药通过重复给药皮肤的治疗范围内造成的，更可靠地在负责管理的生长因子的预定用量在真皮预期任意深度，在预期的效果展品 ，避免色素沉着的副作用。 到该溶液问题是微针制备给药装置，包括：引导管; 基座，其中至少包括其前端面的一部分被引导管和在长度方向上滑动，内坐落; 和驱动装置，用于驱动所述基座向所述引导管的前端部，以及微针制剂是将被安装在台座的前端面，和微针的制剂是为从导向件的前端部压出 管，worin微针制备具有包括前端部和目标物质的含，和具有第二部分的底部部分和不包含目标物质，和台座的前端面在被击打在皮肤上的第一部分 的30 N至200N碰撞压力每1cm 2。
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2.发明公开MICRONEEDLE PATCH, METHOD FOR MANUFACTURING SAME, AND APPARATUS FOR MANUFACTURING MICRONEEDLE ARRAY 审中-公开MICRONEEDLE PATCH，其制造方法及用于制造MICRONEEDLE ARRAY的装置
公开(公告)号：EP3235538A1
公开(公告)日：2017-10-25
申请号：EP15869985.0
申请日：2015-12-15
发明人： ONO, Ichiro , YAMADA, Shinya , CHIYAMA, Masateru , AKITA, Kensaku , UENO, Takako , IDE, Yuko , NAGAI, Sachi , AKAO, Osanobu , TAKADA, Kanji
CPC分类号： B29C39/24 , A61M37/00 , A61M37/0015 , A61M2037/0053 , B05B12/122 , B29C65/004 , B29L2031/7544 , B81B1/00
摘要： A microneedle patch with which a treatment is reliably completed in a short time when a microneedle is administered into skin or mucous membrane is provided. A microneedle patch (100F) includes a base member (101) and a plurality of microneedles (103g) supported by the base member (101). Each microneedle (103g) includes a top-section layer (104) comprising a biologically active substance to be inserted in dermis (310), and an intermediate layer (106) provided between the top-section layer (104) and the base member (101), having a composition having breaking strength weaker than breaking strength of a composition of the top-section layer (104), and having a thickness of 5 µm and 100 µm inclusive.
摘要翻译： 本发明提供一种微针贴片，该微针贴片在向皮肤或粘膜给予微针时能够在短时间内可靠地完成治疗。 微针贴片（100F）包括基座构件（101）和由基座构件（101）支撑的多个微针（103g）。 每个微针103g包括包含待插入真皮310中的生物活性物质的顶层部分104以及设置在顶层部分104和基底部件103之间的中间层106。 101），其组成具有断裂强度弱于顶部层（104）的组成的断裂强度，并且具有5μm和100μm（包括端值）的厚度。
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3.发明公开
公开(公告)号：EP2263683A1
公开(公告)日：2010-12-22
申请号：EP09723909.9
申请日：2009-03-24
发明人： ONO, Ichiro
CPC分类号： A61K9/0019 , A61K8/66 , A61K9/0021 , A61K38/1825 , A61K2800/91 , A61Q19/08
摘要： It is to provide an agent for preventing and treating skin aging, or an agent for treating skin scar that can exert a sufficient effect. An agent for preventing and treating skin aging comprising bFGF for treating aging of the skin that is administered intradermally or subcutaneously, or an agent for treating skin scar comprising bFGF for treating scar of skin that is administered intradermally or subcutaneously is utilized. Preferred examples of aging of skin include skin wrinkle, pigmented spot, sagging skin, rough skin, skin thinning, decrease of skin viscoelasticity, etc., and preferred examples of scar include keloid, hypertrophic scar, scar contracture, etc.
摘要翻译： 它是提供一种用于预防和治疗皮肤衰老的药剂，或用于治疗可发挥足够效果的皮肤瘢痕的药剂。 利用包含用于治疗皮内或皮下给药的皮肤老化的bFGF或用于治疗皮肤瘢痕的皮肤瘢痕的试剂，用于预防和治疗皮肤老化的试剂，其包含用于治疗皮内或皮下给药的皮肤瘢痕的bFGF。 皮肤老化的优选实例包括皮肤皱纹，着色点，下垂皮肤，粗糙皮肤，皮肤变薄，皮肤粘弹性降低等，并且瘢痕疙瘩，肥厚性瘢痕，瘢痕挛缩等的优选实例。
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公开(公告)号：EP3117867B1
公开(公告)日：2019-07-24
申请号：EP14885596.8
申请日：2014-03-12
发明人： TAKADA, Kanji , ONO, Ichiro
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公开(公告)号：EP3381498A1
公开(公告)日：2018-10-03
申请号：EP16868205.2
申请日：2016-11-25
发明人： ONO, Ichiro
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M37/00 , A61M2037/0023 , A61M2037/0053 , B29C39/123 , B29K2105/0035 , B29K2995/006 , B29L2031/7544 , B29L2031/756
摘要： An object of the present invention is to solve problems of microneedles produced by conventional methods, and provide a microneedle with improved penetrability and shape retainability. A conical microneedle (10) includes a tip part (2) containing a drug and biodegradable polymer, and a base part (4) that does not contain drug, a tip (1) side is formed as a tip-reinforced region (6), a base (3) side adjacent to the tip-reinforced region with or without coating to the tip art of the microneedle(6) is formed as a non-reinforced region (7), and a hardness of the tip-reinforced region (6) is higher than the hardness of the non-reinforced region (7). A microneedle patch including the microneedle (10) according to the present invention can reduce pressing strength on application to a patient, and alleviate pain and fear to the patient.
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公开(公告)号：EP2263683B1
公开(公告)日：2017-09-20
申请号：EP09723909.9
申请日：2009-03-24
发明人： ONO, Ichiro
IPC分类号： A61K38/22 , A61K8/64 , A61P17/00 , A61P17/02 , A61P17/16 , A61Q19/08 , A61K8/66 , A61K9/00 , A61K38/18
CPC分类号： A61K9/0019 , A61K8/66 , A61K9/0021 , A61K38/1825 , A61K2800/91 , A61Q19/08
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公开(公告)号：EP3391935A1
公开(公告)日：2018-10-24
申请号：EP16875132.9
申请日：2016-12-16
发明人： ONO, Ichiro
IPC分类号： A61M37/00
CPC分类号： A61M37/00
摘要： An object of the present invention is to provide a microneedle and a method for producing the same that are specialized for individual treatment purposes and can efficiently achieve a treatment effect. The microneedle according to the present invention relates to a microneedle including a drug containing layer, an intermediate layer, and a base layer in order from a tip side, wherein a boundary between the drug containing layer and the intermediate layer has a shape protruding toward the intermediate layer, and a thickness of a central portion of the intermediate layer is smaller than a thickness of a peripheral edge portion. The microneedle according to the present invention can be more easily broken in the intermediate layer than the conventional microneedle, thereby allowing the drug containing layer to be placed to properly target a particular area in epidermis or dermis. Also, drug release from the drug containing layer can be accurately controlled by a shape, a coating, or the like of the drug containing layer, and a range of application of treatment using a microneedle patch can be extended.
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