公开(公告)号：EP2082042A1

公开(公告)日：2009-07-29

申请号：EP08706301.2

申请日：2008-01-28

申请人： Leclerc, Denis ,  López-Macías, Constantino III Roberto

发明人： Leclerc, Denis ,  López-Macías, Constantino III Roberto

IPC分类号： C12N15/62 ,  A61K39/02 ,  A61K39/112 ,  A61K39/385 ,  A61K39/39 ,  A61P31/04 ,  C07K14/08 ,  C07K14/24 ,  C07K14/255 ,  C07K19/00 ,  C12N15/31 ,  C12N15/40 ,  C12N7/01 ,  C07K7/06

CPC分类号： C07K16/10 ,  A61K39/0011 ,  A61K39/025 ,  A61K39/0275 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/4748 ,  C07K2317/77 ,  C07K2319/735 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/26022 ,  C12N2770/26023 ,  C12N2770/26034 ,  Y02A50/407 ,  Y02A50/482 ,  Y02A50/484

摘要： An antigen-presenting system (APS) comprising one or more enterobacterial antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. The PapMV or VLP included in the APS is capable of potentiating an immune response against said one or more enterobacterial antigens. The APS can be used, for example, as a vaccine against enterobacterial disease, such as typhoid fever. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PapMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP), or the APS can comprise both conjugated and non-conjugated antigens. Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.