公开(公告)号：EP2069503A1

公开(公告)日：2009-06-17

申请号：EP07845539.1

申请日：2007-11-15

申请人： Leclerc, Denis

发明人： Leclerc, Denis

IPC分类号： C12N15/62 ,  A61K39/12 ,  A61K39/145 ,  A61K39/295 ,  A61K39/39 ,  A61K47/48 ,  A61P31/16 ,  A61P37/04 ,  C07K14/08 ,  C07K14/11 ,  C07K19/00 ,  C12N15/40 ,  C12N15/44 ,  C12N7/01

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/6075 ,  A61K2039/64 ,  C07K14/005 ,  C07K2319/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/00022 ,  C12N2770/00023 ,  C12N2770/00043

摘要： An antigen-presenting system (APS) comprising one or more antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. Specifically an APS comprising one or more influenza virus antigens is provided. The APS can be used, for example, as a vaccine against influenza. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PaPMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP). Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.

公开(公告)号：EP2069503A4

公开(公告)日：2010-08-04

申请号：EP07845539

申请日：2007-11-15

申请人： LECLERC DENIS

发明人： LECLERC DENIS

IPC分类号： C12N15/62 ,  A61K9/12 ,  A61K35/76 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61P31/04 ,  A61P31/12

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/6075 ,  A61K2039/64 ,  C07K14/005 ,  C07K2319/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/00022 ,  C12N2770/00023 ,  C12N2770/00043

摘要： An antigen-presenting system (APS) comprising one or more antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. Specifically an APS comprising one or more influenza virus antigens is provided. The APS can be used, for example, as a vaccine against influenza. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PaPMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP). Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.

公开(公告)号：EP2082042A1

公开(公告)日：2009-07-29

申请号：EP08706301.2

申请日：2008-01-28

申请人： Leclerc, Denis ,  López-Macías, Constantino III Roberto

发明人： Leclerc, Denis ,  López-Macías, Constantino III Roberto

IPC分类号： C12N15/62 ,  A61K39/02 ,  A61K39/112 ,  A61K39/385 ,  A61K39/39 ,  A61P31/04 ,  C07K14/08 ,  C07K14/24 ,  C07K14/255 ,  C07K19/00 ,  C12N15/31 ,  C12N15/40 ,  C12N7/01 ,  C07K7/06

CPC分类号： C07K16/10 ,  A61K39/0011 ,  A61K39/025 ,  A61K39/0275 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/4748 ,  C07K2317/77 ,  C07K2319/735 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/26022 ,  C12N2770/26023 ,  C12N2770/26034 ,  Y02A50/407 ,  Y02A50/482 ,  Y02A50/484

摘要： An antigen-presenting system (APS) comprising one or more enterobacterial antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. The PapMV or VLP included in the APS is capable of potentiating an immune response against said one or more enterobacterial antigens. The APS can be used, for example, as a vaccine against enterobacterial disease, such as typhoid fever. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PapMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP), or the APS can comprise both conjugated and non-conjugated antigens. Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.

公开(公告)号：EP1523329A2

公开(公告)日：2005-04-20

申请号：EP03739913.6

申请日：2003-06-30

申请人： Leclerc, Denis ,  Majeau, Nathalie ,  Tessier, Philippe A. ,  Lopez-Macias, Constantino III Roberto

发明人： LECLERC, Denis ,  MAJEAU, Nathalie ,  TESSIER, Philippe ,  LOPEZ-MACIAS, Constantino Roberto, III

IPC分类号： A61K39/00 ,  C12N15/82 ,  A61K39/385 ,  A61K39/39 ,  C07K14/08 ,  C07K14/18 ,  C07K14/255

CPC分类号： A61K39/39 ,  A61K39/385 ,  A61K2039/525 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64 ,  C07K14/005 ,  C07K2319/00 ,  C12N2770/24222 ,  C12N2770/26023 ,  Y02A50/484

摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen -carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen, may be used as a vaccine.

摘要翻译： 本发明涉及具有免疫增强或佐剂性质的免疫原 - 载体。 更特别地，免疫原载体是来自potexvirus家族的病毒样颗粒（VLP），并且最特别是木瓜花叶病毒。 通过重组技术产生的VLP与其自身蛋白质之一融合成蛋白质免疫原。 上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可用作疫苗。