公开(公告)号：EP2707031B1

公开(公告)日：2019-06-26

申请号：EP12782658.4

申请日：2012-05-08

申请人： LegoChem Biosciences, Inc.

发明人： KIM, Yongzu ,  PARK, Taekyo ,  WOO, Sungho ,  LEE, Hyangsook ,  KIM, Youngun ,  CHO, Jongun ,  JUNG, Doohwan ,  KIM, Sunyoung ,  KWON, Hyunjin ,  OH, Kyuman ,  CHUNG, Yunseo ,  PARK, Yun-hee

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K31/70 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32 ,  C12Q1/48 ,  A61K47/65 ,  A61K47/68 ,  A61K47/54 ,  A61K47/55

公开(公告)号：EP3610889A1

公开(公告)日：2020-02-19

申请号：EP19182361.6

申请日：2012-05-08

申请人： LegoChem Biosciences, Inc.

发明人： KIM, Yongzu ,  PARK, Taekyo ,  WOO, Sungho ,  LEE, Hyangsook ,  KIM, Youngun ,  CHO, Jongun ,  JUNG, Doohwan ,  KIM, Sunyoung ,  KWON, Hyunjin ,  OH, Kyuman ,  CHUNG, Yunseo ,  PARK, Yun-hee

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K31/70 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32 ,  C12Q1/48 ,  A61K47/55 ,  A61K47/65 ,  A61K47/68 ,  A61K47/54

摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates, as well as methods for making the conjugates and compositions. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).

公开(公告)号：EP2707031A2

公开(公告)日：2014-03-19

申请号：EP12782658.4

申请日：2012-05-08

申请人： LegoChem Biosciences, Inc.

发明人： KIM, Yongzu ,  PARK, Taekyo ,  WOO, Sungho ,  LEE, Hyangsook ,  KIM, Youngun ,  CHO, Jongun ,  JUNG, Doohwan ,  KIM, Sunyoung ,  KWON, Hyunjin ,  OH, Kyuman ,  CHUNG, Yunseo ,  PARK, Yun-hee

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K47/48 ,  A61K31/70 ,  A61P35/00

CPC分类号： A61K47/6811 ,  A61K47/549 ,  A61K47/55 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6859 ,  A61K47/6889 ,  C07K16/2863 ,  C07K16/32 ,  C12Q1/48

摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates, as well as methods for making the conjugates and compositions. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).

摘要翻译： 本发明提供具有可被类异戊二烯转移酶识别的氨基酸基序的蛋白质 - 活性剂缀合物。 本发明还提供含有缀合物的组合物，以及制备缀合物和组合物的方法。 本发明进一步提供使用缀合物将活性剂递送至靶细胞的方法，以及使用缀合物治疗有需要的受试者（例如需要活性剂的受试者）的方法。