公开(公告)号：EP2706062B1

公开(公告)日：2018-05-09

申请号：EP12765589.2

申请日：2012-03-29

申请人： LegoChem Biosciences, Inc.

发明人： CHO, Young Lag ,  YUN, Joung Yul ,  PARK, Chul Soon ,  CHAE, Sang Eun ,  LEE, Hyang Sook ,  OH, Kyuman ,  HEO, Hye Jin ,  KANG, Dae Hyuck ,  YANG, Young Jae ,  KWON, Hyun Jin ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM, Yong Zu

IPC分类号： C07D501/34 ,  A61K31/546 ,  A61P31/00 ,  C07D501/24 ,  C07D501/46

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R 1 , and R 2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

公开(公告)号：EP2706062A2

公开(公告)日：2014-03-12

申请号：EP12765589.2

申请日：2012-03-29

申请人： LegoChem Biosciences, Inc.

发明人： CHO, Young Lag ,  YUN, Joung Yul ,  PARK, Chul Soon ,  CHAE, Sang Eun ,  LEE, Hyang Sook ,  OH, Kyuman ,  HEO, Hye Jin ,  KANG, Dae Hyuck ,  YANG, Young Jae ,  KWON, Hyun Jin ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM, Yong Zu

IPC分类号： C07D501/34 ,  A61K31/546 ,  A61P31/00

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1.

Wherein, X, Y, L, R 1 , and R 2 are as same as defined in the description of the invention.
The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient.
According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

摘要翻译： 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的说明书中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂化物，其异构体或其药学上可接受的盐作为有效成分。 根据本发明，新型头孢菌素衍生物，其前体药物，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为广谱抗生素抗性，低毒性，特别是革兰氏阳性的有效成分 - 阴性细菌，其可用于具有强的抗微生物活性。