公开(公告)号：EP2706062A2

公开(公告)日：2014-03-12

申请号：EP12765589.2

申请日：2012-03-29

申请人： LegoChem Biosciences, Inc.

发明人： CHO, Young Lag ,  YUN, Joung Yul ,  PARK, Chul Soon ,  CHAE, Sang Eun ,  LEE, Hyang Sook ,  OH, Kyuman ,  HEO, Hye Jin ,  KANG, Dae Hyuck ,  YANG, Young Jae ,  KWON, Hyun Jin ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM, Yong Zu

IPC分类号： C07D501/34 ,  A61K31/546 ,  A61P31/00

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1.

Wherein, X, Y, L, R 1 , and R 2 are as same as defined in the description of the invention.
The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient.
According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

摘要翻译： 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的说明书中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂化物，其异构体或其药学上可接受的盐作为有效成分。 根据本发明，新型头孢菌素衍生物，其前体药物，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为广谱抗生素抗性，低毒性，特别是革兰氏阳性的有效成分 - 阴性细菌，其可用于具有强的抗微生物活性。

公开(公告)号：EP2692727A2

公开(公告)日：2014-02-05

申请号：EP12764499.5

申请日：2012-03-29

申请人： LegoChem Biosciences, Inc.

发明人： CHO, Young Lag ,  BAEK, Sung Yoon ,  CHAE, Sang Eun ,  KIM, Sun Young ,  LEE, Hong Bum ,  LEE, Hyang Sook ,  OH, Kyuman ,  HEO, Hye Jin ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM, Yong Zu

IPC分类号： C07D413/14 ,  A61K31/53 ,  A61P31/04

CPC分类号： C07D413/14

摘要： Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.
In Formula 1, R and Q are the same as defined in the detailed description.
In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.
The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.

公开(公告)号：EP2706062B1

公开(公告)日：2018-05-09

申请号：EP12765589.2

申请日：2012-03-29

申请人： LegoChem Biosciences, Inc.

发明人： CHO, Young Lag ,  YUN, Joung Yul ,  PARK, Chul Soon ,  CHAE, Sang Eun ,  LEE, Hyang Sook ,  OH, Kyuman ,  HEO, Hye Jin ,  KANG, Dae Hyuck ,  YANG, Young Jae ,  KWON, Hyun Jin ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM, Yong Zu

IPC分类号： C07D501/34 ,  A61K31/546 ,  A61P31/00 ,  C07D501/24 ,  C07D501/46

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R 1 , and R 2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

公开(公告)号：EP2331529B1

公开(公告)日：2014-11-05

申请号：EP09816393.4

申请日：2009-09-22

申请人： LegoChem Biosciences, Inc.

发明人： CHO, Young Lag ,  CHAE, Sang Eun ,  BAEK, Sung Yoon ,  KIM, Yeon Ok ,  KIM, Seong Jin ,  LEE, Hyang Sook ,  PARK, Ju Hyun ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM,Yong Zu

IPC分类号： C07D403/08 ,  A61K31/497 ,  A61K31/53 ,  A61P31/04

CPC分类号： C07D403/08

公开(公告)号：EP3156424A1

公开(公告)日：2017-04-19

申请号：EP15799360.1

申请日：2015-05-27

申请人： LegoChem Biosciences, Inc.

发明人： KIM, Yong Zu ,  PARK, Tae Kyo ,  WOO, Sung Ho ,  KIM, Sun Young ,  CHO, Jong Un ,  JUNG, Doo Hwan ,  YANG, Jeon ,  MIN, Ji Young ,  LEE, Hyang Sook ,  PARK, Yun Hee ,  RYU, Jeong Hee ,  OH, Kyu Man ,  OH, Yeong Soo ,  CHAE, Jeiwook ,  SONG, Ho Young ,  CHUNG, Chul-Woong

IPC分类号： C07K19/00 ,  C07D249/04

CPC分类号： A61K47/6871 ,  A61K47/549 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6855 ,  A61K47/6889 ,  A61K47/69 ,  A61K2039/505 ,  C07D249/04 ,  C07D487/04 ,  C07D519/00 ,  C07K16/32 ,  C07K19/00 ,  C07K2317/24

摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.

摘要翻译： 本发明提供的是包含自褪色基团的化合物，并且根据本发明的包含自褪色基团的化合物可以包含具有底物特异性的蛋白质（例如，寡肽，多肽，抗体等） 具有特定功能或活性的靶和活性剂（例如药物，毒素，配体，检测探针等）。