公开(公告)号：EP3790591A2

公开(公告)日：2021-03-17

申请号：EP19799713.3

申请日：2019-05-09

申请人： LegoChem Biosciences, Inc. ,  Novimmune S.A.

发明人： SONG, Ho Young ,  PARK, Yun Hee ,  KIM, Sung Min ,  KIM, Hyoung Rae ,  OH, Ji Hye ,  RYU, Hyun Min ,  CHAE, Jeiwook ,  OH, Yeong Soo ,  KIM, Yong Zu ,  DEEHAN, Maureen ,  FISCHER, Nicolas

IPC分类号： A61K47/68 ,  A61K31/5517 ,  A61K31/7052 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07K16/28

公开(公告)号：EP4025257A1

公开(公告)日：2022-07-13

申请号：EP20861806.6

申请日：2020-07-27

申请人： LegoChem Biosciences, Inc. ,  ABL Bio, Inc.

发明人： PARK, Yun Hee ,  SONG, Ho Young ,  RYU, Hyun Min ,  KIM, Sung Min ,  BAEK, Ju Yuel ,  OH, Ji Hye ,  HAN, Nara ,  KIM, Hyoung Rae ,  PARK, Kyung Eun ,  LEE, Hyeun Joung ,  LEE, Ju Young ,  KANG, Dae Hyuck ,  YANG, Young-Jae ,  YOU, Ji-Na ,  KIM, Yong Zu ,  LEE, Chang Sun ,  CHAE, Jeiwook ,  JUNG, Jinwon ,  KIM. Juhee ,  LEE, Bora ,  SONG, Daehae ,  SUNG, Byungje ,  YEOM, Donghoon ,  EOM, Jaehyun ,  HONG, Youngeun ,  AHN, Jinhyung ,  LEE, Yangsoon ,  PARK, Kyungjin ,  YOO, Jiseon ,  PARK, Minji

IPC分类号： A61K47/68 ,  A61K31/5517 ,  A61P35/00 ,  C07K16/28

公开(公告)号：EP4086268A1

公开(公告)日：2022-11-09

申请号：EP20908515.8

申请日：2020-12-30

申请人： LegoChem Biosciences, Inc.

发明人： SONG, Ho Young ,  PARK, Yun-Hee ,  LEE, Kun Jung ,  OH, Ji Hye ,  KIM, Sung Min ,  PARK, Kyung Eun ,  PARK, Yong Gyu ,  RYU, Hyun Min ,  HAN, Na Ra ,  CHUNG, Chul Woong ,  CHAE, Jei Wook ,  KIM, Yong Zu

IPC分类号： C07H15/26 ,  A61K31/7056 ,  A61P35/00

摘要： The present invention relates to a pyrrolobenzodiazepine derivative compound, a conjugate of the same with a ligand, and the use of the same. The pyrrolobenzodiazepine derivative compound is more stable in plasma, is stable even in circulation, and exhibits excellent efficacy. In particular, the conjugate of the pyrrolobenzodiazepine derivative compound with a ligand has a great advantage in that it is possible to target and specifically treat proliferative disease such as cancer, maximize drug efficacy, and minimize the expression of side effects since the conjugate more stably reaches the target cell and effectively exerts drug efficacy while toxicity is greatly reduced as a linker technology that allows drugs to be easily released within cancer cells and maximize drug efficacy is incorporated.