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公开(公告)号：EP4025257A1
公开(公告)日：2022-07-13
申请号：EP20861806.6
申请日：2020-07-27
发明人： PARK, Yun Hee , SONG, Ho Young , RYU, Hyun Min , KIM, Sung Min , BAEK, Ju Yuel , OH, Ji Hye , HAN, Nara , KIM, Hyoung Rae , PARK, Kyung Eun , LEE, Hyeun Joung , LEE, Ju Young , KANG, Dae Hyuck , YANG, Young-Jae , YOU, Ji-Na , KIM, Yong Zu , LEE, Chang Sun , CHAE, Jeiwook , JUNG, Jinwon , KIM. Juhee , LEE, Bora , SONG, Daehae , SUNG, Byungje , YEOM, Donghoon , EOM, Jaehyun , HONG, Youngeun , AHN, Jinhyung , LEE, Yangsoon , PARK, Kyungjin , YOO, Jiseon , PARK, Minji
IPC分类号： A61K47/68 , A61K31/5517 , A61P35/00 , C07K16/28
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公开(公告)号：EP3380125A1
公开(公告)日：2018-10-03
申请号：EP16868095.7
申请日：2016-11-23
发明人： KIM, Yong Zu , OH, Yeong Soo , CHAE, Jeiwook , SONG, Ho Young , CHUNG, Chul-Woong , PARK, Yun Hee , CHOI, Hyo Jung , PARK, Kyung Eun , KIM, Hyoungrae , KIM, Jinyeong , MIN, Ji Young , KIM, Sung Min , LEE, Byung Soo , WOO, Dong Hyun , JUNG, Ji Eun , LEE, Su In
CPC分类号： A61K47/6863 , A61K47/6803 , A61K47/6855 , A61K47/6857 , A61K47/6889
摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：EP3790591A2
公开(公告)日：2021-03-17
申请号：EP19799713.3
申请日：2019-05-09
发明人： SONG, Ho Young , PARK, Yun Hee , KIM, Sung Min , KIM, Hyoung Rae , OH, Ji Hye , RYU, Hyun Min , CHAE, Jeiwook , OH, Yeong Soo , KIM, Yong Zu , DEEHAN, Maureen , FISCHER, Nicolas
IPC分类号： A61K47/68 , A61K31/5517 , A61K31/7052 , A61K45/06 , A61P35/00 , A61P37/00 , C07K16/28
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公开(公告)号：EP3380124A1
公开(公告)日：2018-10-03
申请号：EP16868091.6
申请日：2016-11-23
发明人： KIM, Yong Zu , OH, Yeong Soo , CHAE, Jeiwook , SONG, Ho Young , CHUNG, Chul-Woong , PARK, Yun Hee , CHOI, Hyo Jung , PARK, Kyung Eun , KIM, Hyoungrae , KIM, Jinyeong , MIN, Ji, Young , KIM, Sung, Min , LEE, Byung Soo , WOO, Dong Hyun , JUN, Ji Eun , LEE, Su In
CPC分类号： A61K47/6811 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/6845 , A61K47/6855 , A61K47/6867 , A61K47/6889 , Y02A50/471 , Y02A50/475
摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：EP3380126A1
公开(公告)日：2018-10-03
申请号：EP16868096.5
申请日：2016-11-23
发明人： KIM, Yong Zu , OH, Yeong Soo , CHAE, Jeiwook , SONG, Ho Young , CHUNG, Chul-Woong , PARK, Yun Hee , CHOI, Hyo Jung , PARK, Kyung Eun , KIM, Hyoungrae , KIM, Jinyeong , MIN, Ji Young , KIM, Sung Min , LEE, Byung Soo , WOO, Dong Hyun , JUNG, Ji Eun , LEE, Su In
CPC分类号： A61K47/6883 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K47/6889
摘要： The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody.
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公开(公告)号：EP3156424A1
公开(公告)日：2017-04-19
申请号：EP15799360.1
申请日：2015-05-27
发明人： KIM, Yong Zu , PARK, Tae Kyo , WOO, Sung Ho , KIM, Sun Young , CHO, Jong Un , JUNG, Doo Hwan , YANG, Jeon , MIN, Ji Young , LEE, Hyang Sook , PARK, Yun Hee , RYU, Jeong Hee , OH, Kyu Man , OH, Yeong Soo , CHAE, Jeiwook , SONG, Ho Young , CHUNG, Chul-Woong
IPC分类号： C07K19/00 , C07D249/04
CPC分类号： A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
摘要翻译： 本发明提供的是包含自褪色基团的化合物，并且根据本发明的包含自褪色基团的化合物可以包含具有底物特异性的蛋白质（例如，寡肽，多肽，抗体等） 具有特定功能或活性的靶和活性剂（例如药物，毒素，配体，检测探针等）。
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