-
1.发明公开PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS 失效工艺生产具有ACE锁定效果因此，新的化合物BON领带有用作为原材料和链接SAID之程序
公开(公告)号：EP0719280A1
公开(公告)日：1996-07-03
申请号：EP95925228.0
申请日：1995-07-13
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07K5/0222
摘要： There is disclosed a process for the preparation of compounds having ACE inhibitory action of formula (1) wherein R has the meanings as in claim 1, wherein the stereospecific amino acid N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine is carboxylically activated with a thionyl chloride derivative wherein at least one chlorine atom is replaced by the residue of a heterocylic ambident compound such as imidazole, benzimidazole, 2-methylimidazole or triazole, especially chlorothionylimidazole or thionyldiimidazole, in the presence of an organic solvent to the intermediate novel compound A or to the intermediate novel compound B and the obtained intermediate compound is reacted with an amino acid, preferably in the monosilylated form, most preferably in the disilylated form. Disclosed are also novel compounds useful as starting materials or intermediates in the present process.
-
2.发明授权PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS 失效工艺对化合物ACE锁定效果。因此新化合物的作为起始物质制备及之间的SAID方法的连接
公开(公告)号：EP0719280B1
公开(公告)日：1999-11-10
申请号：EP95925228.9
申请日：1995-07-13
IPC分类号： C07K5/02 , C07D233/61
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07K5/0222
摘要： There is disclosed a process for the preparation of compounds having ACE inhibitory action of formula (1) wherein R has the meanings as in claim 1, wherein the stereospecific amino acid N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine is carboxylically activated with a thionyl chloride derivative wherein at least one chlorine atom is replaced by the residue of a heterocylic ambident compound such as imidazole, benzimidazole, 2-methylimidazole or triazole, especially chlorothionylimidazole or thionyldiimidazole, in the presence of an organic solvent to the intermediate novel compound A or to the intermediate novel compound B and the obtained intermediate compound is reacted with an amino acid, preferably in the monosilylated form, most preferably in the disilylated form. Disclosed are also novel compounds useful as starting materials or intermediates in the present process.
-
搜索结果
2 条记录 (耗时 0.013 秒)
