专利检索 ap:("Lek Tovarna Farmacevtskih in Kemicnih Izdelkov, D.D.") AND inv:"SALOBIR, Mateja" 第 1 页

1.

发明公开
DIRECTLY COMPRESSIBLE MATRIX FOR CONTROLLED RELEASE OF SINGLE DAILY DOSES OF CLARITHROMYCIN 有权
标题翻译： DIREKTVERPRESSBARE矩阵的克拉霉素，每日一次剂量的控制分布

公开(公告)号：EP1150686A1

公开(公告)日：2001-11-07

申请号：EP00905514.6

申请日：2000-02-17

申请人： Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov D.D.

发明人： FERCEJ TEMELJOTOV, Darja; , MOHAR, Milojka; , SALOBIR, Mateja , REBIC, Ljubomira, Barbara; , OPRESNIK, Marko

IPC分类号： A61K31/70 , A61K9/20 , A61K9/28

CPC分类号： A61K31/7048 , A61K9/2013 , A61K9/2054 , A61K9/2866

摘要： The invention refers to an improved pharmaceutical formulation for controlled release of clarithromycin or its derivatives, enabled by a novel combined matrix consisting of a fatty and a hydrophilic component, whereto also a surfactant and a pH-modulator may be added when an additional influence on the release profile of the active substance is desired.

2.

发明公开
MELT GRANULATION 审中-公开
标题翻译：熔体造粒

公开(公告)号：EP1183013A2

公开(公告)日：2002-03-06

申请号：EP00931886.6

申请日：2000-05-18

申请人： Lek Tovarna Farmacevtskih in Kemicnih Izdelkov, D.D.

发明人： FERCEJ TEMELJOTOV, Darja; , SIRCA, Judita , MOHAR, Milojka; , SALOBIR, Mateja , GOLMAJER, Andrej; , OPRESNIK, Marko

IPC分类号： A61K9/16 , A61K9/52 , A61K31/7048 , A61P31/04 , A61K9/00

CPC分类号： A61K9/0095 , A61K9/1617 , A61K9/1694 , A61K9/5026

摘要： The present invention discloses a simple one-step process of coating by means of melt granulation for effective masking of bitterness, and a new, patient-friendly oral pharmaceutical formulation suitable also for diabetics, which at the same time also enables variations in the rate and site of the release of the active component.