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1.发明授权COMPOSES PYRIDOPYRIMIDINONE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权PYRIDOPYRIMIDINON衍生物，用于生产和含有药物组合物
公开(公告)号：EP1560826B1
公开(公告)日：2006-04-12
申请号：EP03767886.9
申请日：2003-11-04
发明人： RAULT, Sylvain , LANCELOT, Jean-Charles , KOPP, Marina , CAIGNARD, Daniel-Henri , PFEIFFER, Buno , RENARD, Pierre
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04
摘要： Compounds of formula (I), where: R1, R2, R3, R4 are as defined in the description, the enantiomers, diastereomers, tautomers and addition salts thereof with a pharmaceutically-acceptable acid or base. Said compounds have kinase modulating properties and are useful in the treatment of cancer, diabetes, obesity etc.
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2.发明公开DERIVES D'IMIDAZOPYRIDINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权IMIDAZOPYRIN衍生物，工艺用于生产和装有药剂一起住区
公开(公告)号：EP1558612A1
公开(公告)日：2005-08-03
申请号：EP03767889.3
申请日：2003-11-04
发明人： RAULT, Sylvain , LANCELOT, Jean-Charles , KOPP, Marina , CAIGNARD, Daniel-Henri , PFEIFFER, Bruno , RENARD, Pierre , BIZOT-ESPIARD, Jean-Guy
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： The invention concerns compounds of formula (I), wherein R1 represents a hydrogen, halogen atom, an alkyl, polyhalogenoalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkylaminocarbonyl group; R2 represents a hydrogen atom, an alkyl, aryl group optionally substituted, heteroaryl optionally substituted or a R20-C(X) group, R20 representing an alkyl, alkoxy, amino, alkylamino, dialkylamino, aryl optionally substituted or heteroaryl group; X represents an oxygen atom, a sulphur atom, or a NR21 group, wherein R21 represents a hydrogen atom or an alkyl group; R3 represents a hydrogen atom or an alkyl group; n represents an integer between 1 and 6 inclusively, R1 has the following meanings (A); their enantiomers, diastereoisomers, as well as their addition salt to a pharmaceutically acceptable acid or base. The invention is useful for preparing medicines.
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3.发明授权DERIVES D'IMIDAZOPYRIDINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权IMIDAZOPYRIN衍生物，工艺用于生产和装有药剂一起住区
公开(公告)号：EP1558612B1
公开(公告)日：2006-08-23
申请号：EP03767889.3
申请日：2003-11-04
发明人： RAULT, Sylvain , LANCELOT, Jean-Charles , KOPP, Marina , CAIGNARD, Daniel-Henri , PFEIFFER, Bruno , RENARD, Pierre , BIZOT-ESPIARD, Jean-Guy
IPC分类号： C07D471/04 , A61K31/44 , C07D235/00 , C07D221/00
CPC分类号： C07D471/04
摘要： The invention concerns compounds of formula (I), wherein R1 represents a hydrogen, halogen atom, an alkyl, polyhalogenoalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkylaminocarbonyl group; R2 represents a hydrogen atom, an alkyl, aryl group optionally substituted, heteroaryl optionally substituted or a R20-C(X) group, R20 representing an alkyl, alkoxy, amino, alkylamino, dialkylamino, aryl optionally substituted or heteroaryl group; X represents an oxygen atom, a sulphur atom, or a NR21 group, wherein R21 represents a hydrogen atom or an alkyl group; R3 represents a hydrogen atom or an alkyl group; n represents an integer between 1 and 6 inclusively, R1 has the following meanings (A); their enantiomers, diastereoisomers, as well as their addition salt to a pharmaceutically acceptable acid or base. The invention is useful for preparing medicines.
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4.发明公开COMP0SES PYRIDOPYRIMIDINONE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权PYRIDOPYRIMIDINON衍生物，用于生产和含有药物组合物
公开(公告)号：EP1560826A1
公开(公告)日：2005-08-10
申请号：EP03767886.9
申请日：2003-11-04
发明人： RAULT, Sylvain , LANCELOT, Jean-Charles , KOPP, Marina , CAIGNARD, Daniel-Henri , PFEIFFER, Buno , RENARD, Pierre
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04
摘要： Compounds of formula (I), where: R1, R2, R3, R4 are as defined in the description, the enantiomers, diastereomers, tautomers and addition salts thereof with a pharmaceutically-acceptable acid or base. Said compounds have kinase modulating properties and are useful in the treatment of cancer, diabetes, obesity etc.
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