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1.发明公开COMP0SES PYRIDOPYRIMIDINONE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权PYRIDOPYRIMIDINON衍生物，用于生产和含有药物组合物
公开(公告)号：EP1560826A1
公开(公告)日：2005-08-10
申请号：EP03767886.9
申请日：2003-11-04
发明人： RAULT, Sylvain , LANCELOT, Jean-Charles , KOPP, Marina , CAIGNARD, Daniel-Henri , PFEIFFER, Buno , RENARD, Pierre
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04
摘要： Compounds of formula (I), where: R1, R2, R3, R4 are as defined in the description, the enantiomers, diastereomers, tautomers and addition salts thereof with a pharmaceutically-acceptable acid or base. Said compounds have kinase modulating properties and are useful in the treatment of cancer, diabetes, obesity etc.
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2.发明公开DERIVES DE BENZO (E) (1,4) OXAZINO (3,2-G) ISOINDOLE SUBSTI TUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权苯并（E）（1.4）恶嗪（3.2克）异吲哚衍生物，用于生产和含有这些药物组合物
公开(公告)号：EP1556387A1
公开(公告)日：2005-07-27
申请号：EP03809362.1
申请日：2003-10-17
发明人： COUDERT, Gérard , LEPIFRE, Franck , CAIGNARD, Daniel-Henri , RENARD, Pierre , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence
IPC分类号： C07D498/04 , A61K31/535 , C07D498/14 , C07D265/38
CPC分类号： C07D497/04 , C07D497/14
摘要： The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 arylalkyl, aryloxy, linear or branched C1-C6 arylalkoxy, hydroxy, linear or branched C1-C6 alkoxy group; R1 is such as defined in the description; R2 represents a hydrogen atom or a group of formula -CH2CH2O-R8; R3, R4 represent each a hydrogen atom, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 aryalkyl group; n represents an integer between 1 and 6 inclusive. The invention is useful for preparing medicines.
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3.发明公开NOUVEAUX DERIVES D'HYDROXYALKYLE INDOLOCARBAZOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开羟INDOLOKARBAZOLDERIVATE，其制造方法相同，药物组合物含
公开(公告)号：EP1438320A1
公开(公告)日：2004-07-21
申请号：EP02796813.0
申请日：2002-10-21
发明人： PRUDHOMME, Michelle , MARMINON, Christelle , MOREAU, Pascale , HICKMAN, John , PIERRE, Alain , PFEIFFER, Bruno , RENARD, Pierre , BIZOT-ESPIARD, Jean-Guy
IPC分类号： C07H19/23 , A61K31/7056 , A61P25/00 , A61P35/00
CPC分类号： C07H19/23
摘要： The invention concerns a compound of formula (I), wherein: R1 and R2 represent each a group selected among hydrogen, alkyl, arylalkyl, hydroxy, hydroxylalkyl, dihydroxyalkyl, alkoxy, alkoxyalkyl, amino and aminoalkyl (optionally substituted); Ra and Rb represent each an alkylene chain; X1 and X2 represent each a group selected among hydroxy, alkoxy, aryloxy, arylalkoxy, alkyl, amino (optionally substituted), halogen, alkylcarbonyloxy and azido; X4 represent a methylidene group or a group of formula -Rc-X1 such as defined in their description; their isomers and their addition salts to a pharmaceutically acceptable acid or base. The invention is for use as medicines.
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公开(公告)号：EP1320528A2
公开(公告)日：2003-06-25
申请号：EP01958282.4
申请日：2001-06-27
申请人： THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMYOF MEDICAL SCIENCES , Les Laboratoires Servier
发明人： GUO, Zongru , CHU, Fengming , ZHANG, Juntian , YANG, Guangzhong , XU, Bailing , NIU, Xinyi , REN, Zhihong , LESTAGE, Pierre , RENARD, Pierre
IPC分类号： C07D307/88 , A61K31/34 , A61P15/00
CPC分类号： C07D239/42 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula (I): wherein R1 represents an alkyl or ureido group, R2 represents an alkyl group or a hydrogen atom, or R?1 and R2¿ together form a 5- or 6-membered ring, R3 represents a group CN, NO¿2?, NRaR'a, NRaSO2,R'aCZR?5¿ or CZNR¿a?R'a, R?4¿ represents a hydrogen atom or a group R3.
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5.发明授权
公开(公告)号：EP1252150B1
公开(公告)日：2003-06-04
申请号：EP01904021.1
申请日：2001-02-01
发明人： LESIEUR, Daniel , BLANC-DELMAS, Elodie , YOUS, Said , DEPREUX, Patrick , GUILLAUMET, Gérald , DACQUET, Catherine , LEVENS, Nigel , BOUTIN, Jean Albert , BENNEJEAN, Caroline , RENARD, Pierre
IPC分类号： C07D263/58 , C07D277/68 , C07D417/06 , C07D498/04 , C07D471/04 , A61K31/423 , A61K31/428 , A61K31/4353 , A61P3/10 , A61P3/06
CPC分类号： C07D263/58 , C07D277/68 , C07D471/04
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6.发明授权DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权DER 9-AMINO-PODOPHYLLOXOXINE，LEUR PROCEDE DE PREPARATION ET LES组合物药物组合物QUI LES CONTIENNENT
公开(公告)号：EP1664055B1
公开(公告)日：2006-12-13
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译： 烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基， 膦酸和Si（Ra）2Rb，Y是选自HN-NH和NR 2的基团，R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体 及其盐。
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7.发明授权COMPOSES PYRIDOPYRIMIDINONE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权PYRIDOPYRIMIDINON衍生物，用于生产和含有药物组合物
公开(公告)号：EP1560826B1
公开(公告)日：2006-04-12
申请号：EP03767886.9
申请日：2003-11-04
发明人： RAULT, Sylvain , LANCELOT, Jean-Charles , KOPP, Marina , CAIGNARD, Daniel-Henri , PFEIFFER, Buno , RENARD, Pierre
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04
摘要： Compounds of formula (I), where: R1, R2, R3, R4 are as defined in the description, the enantiomers, diastereomers, tautomers and addition salts thereof with a pharmaceutically-acceptable acid or base. Said compounds have kinase modulating properties and are useful in the treatment of cancer, diabetes, obesity etc.
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8.发明授权
公开(公告)号：EP1077927B1
公开(公告)日：2005-12-07
申请号：EP99918036.7
申请日：1999-05-10
发明人： LESIEUR, Daniel , KLUPSCH, Frédérique , GUILLAUMET, Gérald , VIAUD, Marie-Claude , LANGLOIS, Michel , BENNEJEAN, Caroline , RENARD, Pierre , DELAGRANGE, Philippe
IPC分类号： C07C233/36 , C07C233/40 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07D209/60 , C07D221/10 , C07D295/12 , C07D307/81 , C07D333/58 , C07D335/08 , C07D407/12 , C07D471/04 , C07D495/04 , A61K31/165
CPC分类号： C07D207/27 , C04B35/632 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C275/24 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/14 , C07D209/20 , C07D209/60 , C07D213/70 , C07D221/10 , C07D231/12 , C07D233/42 , C07D233/56 , C07D233/84 , C07D235/06 , C07D249/08 , C07D261/20 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/06 , C07D405/12 , C07D407/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14
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9.发明公开
公开(公告)号：EP1590355A1
公开(公告)日：2005-11-02
申请号：EP04707554.4
申请日：2004-02-03
发明人： GALLET, Sébastien , BERTHELOT, Pascal , LEBEGUE, Nicolas , FLOUQUET, Nathalie , CARATO, Pascal , HICKMAN, John , PIERRE, Alain , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D513/04 , C07D515/04 , A61K31/55
CPC分类号： C07D513/04 , C07D515/04
摘要： The invention relates to compounds of formula (I), where (a) is a benzyl or pyridyl group, optionally fused at position ( 2-3, 3-4, or 4-5), and optionally substituted, (W) is a X-Y or Y-X group, where (X) is a group (b) and (Y) is an oxygen atom or a (N-R3) group, n is zero or a whole number where 1 = n = 6 and G, R1, R2 and R3 are as defined in the description, the enantiomers, diastereomers and the addition salts thereof with a pharmaceutically-acceptable acid or base. The invention relates to medicaments.
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10.发明授权
公开(公告)号：EP1292597B1
公开(公告)日：2004-03-17
申请号：EP01947525.0
申请日：2001-06-19
发明人： MONNERET, Claude , BERTOUNESQUE, Emmanuel , MERESSE, Philippe , ATASSI, Ghanem , PIERRE, Alain , HICKMAN, John , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/365 , A61P35/00
CPC分类号： C07D493/04 , Y02P20/55
摘要： A compound selected from these of formula (I):wherein:R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono,R2 represents oxygen or sulphur,R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl,X represents linear or branched (C1-C6)alkylene,R4 represents a group selected from amino optionally substituted by one or two groups, -N(R3)-X1-OR5 wherein R3, X1 and R5 are as defined in the description, -N(R3)-X1-NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, -O-X1-OR5 wherein R5 and X1 are as defined in the description, and -O-X1-NR6R7 wherein R6, R7 and X1 are as defined in the description,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.
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