公开(公告)号：EP1713325A2

公开(公告)日：2006-10-25

申请号：EP05712242.6

申请日：2005-01-27

申请人： Lexicon Genetics Incorporated

发明人： EDWARDS, Joel ,  HUANG, Wenhu ,  MONTGOMERY, Chuck ,  QIAN, Ni Nancy ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  VOGEL, Peter ,  WESTBROOK, Mindy

IPC分类号： A01K67/027 ,  C07K14/47

CPC分类号： C07K14/47 ,  A01K2217/075

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.