公开(公告)号：EP1713325A2

公开(公告)日：2006-10-25

申请号：EP05712242.6

申请日：2005-01-27

申请人： Lexicon Genetics Incorporated

发明人： EDWARDS, Joel ,  HUANG, Wenhu ,  MONTGOMERY, Chuck ,  QIAN, Ni Nancy ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  VOGEL, Peter ,  WESTBROOK, Mindy

IPC分类号： A01K67/027 ,  C07K14/47

CPC分类号： C07K14/47 ,  A01K2217/075

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1744620A2

公开(公告)日：2007-01-24

申请号：EP05736493.7

申请日：2005-04-12

申请人： GENENTECH, INC. ,  Lexicon Genetics Incorporated

发明人： BRENNAN, Jane ,  DESAUVAGE, Frederic ,  EDWARDS, Joel ,  FILVAROFF, Ellen ,  GREWAL, Iqbal ,  HUANG, Wenhu ,  IRVING, Bryan ,  JUNUTULA, Jagath Reddy ,  KIRCHHOFER, Daniel J. ,  MONTGOMERY, Chuck ,  PAYNE, Bobby Joe ,  PEALE JR., Franklin ,  PHILLIPS, Heidi ,  QIAN, Ni Nancy ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  STALA, Joy ,  TANG, Tracy Tzu-Ling ,  VOGEL, Peter ,  YE, Weilan

IPC分类号： A01K67/027 ,  C12N15/85 ,  G01N33/50 ,  C12N5/10 ,  C12N15/12 ,  C12N15/15 ,  C12N15/24 ,  C12N15/52 ,  C12N15/55 ,  C12N15/57 ,  A61K49/00

CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008 ,  C07K14/4703 ,  C07K14/705 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1781824A2

公开(公告)日：2007-05-09

申请号：EP05793413.5

申请日：2005-08-23

申请人： GENENTECH, INC. ,  Lexicon Genetics Incorporated

发明人： BRENNAN, Jane ,  DESAUVAGE, Frederic ,  EDWARDS, Joel ,  HUANG, Wenhu ,  MONTGOMERY, Chuck ,  PAYNE, Bobby Joe ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  VOGEL, Peter ,  YE, Weilan

IPC分类号： C12Q1/68

CPC分类号： A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1694116A2

公开(公告)日：2006-08-30

申请号：EP04813966.1

申请日：2004-12-13

申请人： GENENTECH, INC. ,  Lexicon Genetics Incorporated

发明人： ANDERSON, Stephen ,  BRENNAN, Jane ,  DESAUVAGE, Frederic ,  DING, Zhiyong ,  EDWARDS, Joel ,  FIKES, Nelda ,  HUANG, Wenhu ,  OUYANG, Wenjun ,  RANGEL, Carolina ,  SANGHA, Mamta ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  TRACKEY, Joseph ,  VETTER, Melissa ,  WANG, Ching-Yun ,  WOODINGS, Jessica

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.