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公开(公告)号：EP3293274B1
公开(公告)日：2020-04-01
申请号：EP17198055.0
申请日：2012-08-10
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公开(公告)号：EP2126072A1
公开(公告)日：2009-12-02
申请号：EP08730418.4
申请日：2008-02-21
发明人： BEECHEM, Joseph , CHOONG, Vi-En , NIKIFOROV, Theo
CPC分类号： C12Q1/6827 , C12Q1/6874 , C12Q2565/518 , C12Q2565/101 , C12Q2563/113
摘要： Provided herein are methods and compositions for real time single molecule sequencing of short nucleotide sequences using nucleotide fluorescent semiconductor nanocrystals-conjugated nucleotide primers.
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公开(公告)号：EP3469078A1
公开(公告)日：2019-04-17
申请号：EP17811116.7
申请日：2017-06-09
发明人： YU, Hua , NIKIFOROV, Theo , ROSENBAUM, Abraham
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公开(公告)号：EP2742151B1
公开(公告)日：2017-10-25
申请号：EP12751661.5
申请日：2012-08-10
发明人： VANDER HORN, Peter , NIKIFOROV, Theo , LUO, Guobin , LANDES, Mindy , MAZUR, Daniel , TOZER, Eileen , LINCECUM, Tommie
CPC分类号： C12N9/1252 , C12Q1/6846 , C12Q1/686 , C12Y207/07007
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.
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公开(公告)号：EP4219739A3
公开(公告)日：2023-08-23
申请号：EP22208638.1
申请日：2014-09-30
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.
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公开(公告)号：EP3293274A3
公开(公告)日：2018-03-28
申请号：EP17198055.0
申请日：2012-08-10
发明人： VANDER HORN, Peter , NIKIFOROV, Theo , LUO, Guobin , LANDES, Mindy , MAZUR, Daniel , TOZER, Eileen , LINCECUM, Tommie
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.
摘要翻译： 本公开提供可用于核酸聚合的组合物，方法，试剂盒，系统和装置。 具体而言，提供了允许核酸扩增的修饰聚合酶及其生物活性片段。 在一个方面，本公开涉及用于核酸测序，基因分型，拷贝数变异分析，配对末端测序和其他形式的遗传分析的修饰的聚合酶。 在一些方面，本公开涉及用于产生供各种下游过程使用的核酸文库或核酸模板的修饰聚合酶。 在一些方面，本公开涉及鉴定可以跨聚合酶的类或家族转移以提供具有改变的催化性质的新聚合酶的同源氨基酸突变。 在一些方面，本公开提供了与参考聚合酶相比具有增强的催化性质的修饰的聚合酶。
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公开(公告)号：EP3293274A2
公开(公告)日：2018-03-14
申请号：EP17198055.0
申请日：2012-08-10
发明人： VANDER HORN, Peter , NIKIFOROV, Theo , LUO, Guobin , LANDES, Mindy , MAZUR, Daniel , TOZER, Eileen , LINCECUM, Tommie
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.
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公开(公告)号：EP4219739A2
公开(公告)日：2023-08-02
申请号：EP22208638.1
申请日：2014-09-30
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.
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公开(公告)号：EP3052652A1
公开(公告)日：2016-08-10
申请号：EP14790851.1
申请日：2014-09-30
CPC分类号： C12N9/1252 , C12Q1/686 , C12Q1/6869
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.
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公开(公告)号：EP2742151A2
公开(公告)日：2014-06-18
申请号：EP12751661.5
申请日：2012-08-10
发明人： VANDER HORN, Peter , NIKIFOROV, Theo , LUO, Guobin , LANDES, Mindy , MAZUR, Daniel , TOZER, Eileen , LINCECUM, Tommie
CPC分类号： C12N9/1252 , C12Q1/6846 , C12Q1/686 , C12Y207/07007
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.
摘要翻译： 本公开提供了可用于核酸聚合的组合物，方法，试剂盒，系统和装置。 特别地，提供了允许核酸扩增的修饰的聚合酶及其生物活性片段。 一方面，本公开涉及可用于核酸测序，基因分型，拷贝数变异分析，配对末端测序和其他形式遗传分析的修饰聚合酶。 在一些方面，本公开涉及可用于产生用于各种下游过程的核酸文库或核酸模板的修饰聚合酶。 在一些方面，本公开涉及可以跨聚合酶类或家族转移的同源氨基酸突变的鉴定，以提供具有改变的催化性质的新型聚合酶。 在一些方面，本公开提供与参考聚合酶相比具有增强的催化性质的改性聚合酶。
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