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公开(公告)号：EP3702383A1
公开(公告)日：2020-09-02
申请号：EP20150423.0
申请日：2016-07-01
发明人： FONNUM, Geir , MENCHEN, Steven M. , GOKMEN, Talha M. , LUNDBERG, Pontus , THWAR, Prasanna Krishnan , LUI, Alfred , LU, Lily , HINZ, Wolfgang , HUSABOE, Lene , BREIVOLD, Elisabeth , MOLTEBERG, Astrid Evenroed , LARSEN, Synne
IPC分类号： C08F220/58 , C08F8/12
摘要： A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：EP3317314B1
公开(公告)日：2020-01-08
申请号：EP16741201.4
申请日：2016-07-01
发明人： FONNUM, Geir , MENCHEN, Steven, M. , GOKMEN, Talha, M. , LUNDBERG, Pontus , THWAR, Prasanna Krishnan , LUI, Alfred , LU, Lily , HINZ, Wolfgang , HUSABOE, Lene , BREIVOLD, Elisabeth , MOLTEBERG, Astrid, Evenroed , LARSEN, Synne
IPC分类号： C08F220/58 , C08F8/12
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公开(公告)号：EP3317426A1
公开(公告)日：2018-05-09
申请号：EP16741745.0
申请日：2016-07-01
发明人： FONNUM, Geir , MENCHEN, Steven M. , LUI, Alfred , XIANG, Guobing , LARSEN, Synne
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6874 , C08J7/14 , C08J2333/26 , C12Q1/6853 , C12Q1/6869 , C12Q1/6876 , C12Q2525/197 , C12Q2527/125 , C12Q2565/607 , C12Q2565/629
摘要： A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
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公开(公告)号：EP3317426B1
公开(公告)日：2020-01-15
申请号：EP16741745.0
申请日：2016-07-01
发明人： FONNUM, Geir , MENCHEN, Steven M. , LUI, Alfred , XIANG, Guobing , LARSEN, Synne
IPC分类号： C12Q1/68 , G01N33/543
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公开(公告)号：EP3317314A1
公开(公告)日：2018-05-09
申请号：EP16741201.4
申请日：2016-07-01
发明人： FONNUM, Geir , MENCHEN, Steven, M. , GOKMEN, Talha, M. , LUNDBERG, Pontus , THWAR, Prasanna Krishnan , LUI, Alfred , LU, Lily , HINZ, Wolfgang , HUSABOE, Lene , BREIVOLD, Elisabeth , MOLTEBERG, Astrid, Evenroed , LARSEN, Synne
IPC分类号： C08F220/58 , C08F8/12
摘要： A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：EP3325522A1
公开(公告)日：2018-05-30
申请号：EP16739524.3
申请日：2016-07-19
申请人： Life Technologies AS
发明人： FONNUM, Geir , LUNDBERG, Per, Nils, Pontus, , GÖKMEN, Muhammed, Talha , LARSEN, Synne , GLOMM, Wilhelm , JOHNSEN, Heidi , SCHMID, Ruth , KILAAS, Lars
IPC分类号： C08F120/54 , C08F2/38 , C08F265/10
CPC分类号： C08F265/10 , C08F120/54 , C08F265/06 , C08F220/56
摘要： This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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