公开(公告)号：EP1001765A1

公开(公告)日：2000-05-24

申请号：EP98915611.2

申请日：1998-04-15

申请人： Light Sciences Limited Partnership

发明人： CHEN, James, C. ,  WISCOMBE, Brent

IPC分类号： A61K31/40 ,  A61K31/555

CPC分类号： A61N5/062 ,  A61K41/008 ,  A61N5/0601 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A plurality of light sources that emit light having a long wavelength are energized for an extended period of time to increase the likelihood of two photon absorption by cells that have preferentially absorbed a photoreactive agent such as psoralen. The cells are preferably microscopic metastatic cancer cells that are diffusely distributed throughout a treatment site, for example, within an organ. The plurality of light sources are arranged in a spaced-apart array, mounted on a support plate that includes a plurality of conductive traces. A plurality of such arrays are preferably mounted to a flexible sheet that can conform to an outer surface of an organ being treated. Because the light emitted by the light sources is in the infrared or near infrared waveband, it penetrates deeply into the tissue at the treatment site. The duration of the treatment and the number of light sources employed for administering the therapy increases the likelihood of two photon absorption by the metastatic cancer cells, which has been shown to activate the photoreactive agent to destroy cancer cells in a tumor, even though the characteristic light absorption waveband of the photoreactive agent is in the ultraviolet waveband.

公开(公告)号：EP0884972A1

公开(公告)日：1998-12-23

申请号：EP97906641.0

申请日：1997-02-14

申请人： Light Sciences Limited Partnership

发明人： CHEN, James, C. ,  WISCOMBE, Brent

IPC分类号： A61B5 ,  A61B17 ,  A61B19 ,  A61N1 ,  A61N5

CPC分类号： A61B17/00234 ,  A61B2017/00243 ,  A61B2017/00274 ,  A61B2017/0404 ,  A61B2017/0458 ,  A61B2018/00547 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/061 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A plurality of embodiments for a flexible probe used to provide photodynamic therapy (PDT) and to effect other medical procedures at an internal treatment site inside a patient's body. Each of the embodiments of the flexible probe (100, 108, 130, 158, 182, 190, 220, 280, 370, 390, 440, 460, 520) includes a flexible substrate (102, 184, 196, 222, 250, 282, 412, 462, 482, 502, 522) on which are disposed conductive traces (414, 466, 468, 488, 490, 504, 506, 524, 526) electrically connected to leads through which electrical current and signals are conveyed. A plurality of light sources (104, 192, 256, 286, 418, 436, 470, 492, 508, 542) or other micro-electronic circuits are connected to the conductive traces and mounted on the flexible substrate. Each of the embodiments of the flexible probes is enclosed within a transparent, biocompatible polymer envelope (106, 110, 464, 522). Due to the characteristic elastic properties of the flexible substrate, the flexible probe can readily be bent, folded or rolled while being disposed at the internal treatment site. Thus, for example, a curved surgical needle (650) can be used to implant a flexible probe at the treatment site by drawing the flexible probe through tissue along a curved path to a desired position; one or more disk-shaped buttons (660, 670) that are attached to the ends of the flexible probe can be used to secure the flexible probe so that it does not move from the desired position.

公开(公告)号：EP1011810A1

公开(公告)日：2000-06-28

申请号：EP97950720.9

申请日：1997-12-01

申请人： Light Sciences Limited Partnership

发明人： CHEN, James, C. ,  WISCOMBE, Brent

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61N5/062 ,  H01L25/0756 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2224/73265 ,  H05K1/189 ,  H01L2924/00014 ,  H01L2924/00

摘要： A flexible probe constructed using a flexible circuit having a small cross-sectional profile. In the various disclosed embodiments of the flexible circuit, a flexible substrate includes a plurality of conductive traces that extend along opposite surfaces of the substrate. Light emitting devices (or other electronic devices) are mounted at spaced-apart intervals along the length of the conductive traces using a conductive adhesive/solder. A conductor couples a terminal on the outwardly facing side of each of the light emitting devices to the conductive trace that is disposed on the opposite side of the substrate. In one embodiment, this conductor comprises a short conductive bar that extends between the terminals of pairs of the light emitting devices that are mounted on opposite sides of the flexible substrate so that the pair of light emitting devices are connected in series. In another embodiment, the flexible substrate includes an outwardly extending arm of the conductive trace that wraps around the edge of the flexible substrate to connect to the light emitting device mounted on the opposite side thereof. In each embodiment, a substantially smaller cross-sectional profile is achieved compared to a previous approach in which the conductive traces providing power to a light emitting device were located on the same side of the flexible substrate and fly wires were used to connect the light emitting devices to the conductive traces.

公开(公告)号：EP1011809A1

公开(公告)日：2000-06-28

申请号：EP97950719.1

申请日：1997-12-01

申请人： Light Sciences Limited Partnership

发明人： CHEN, James, C. ,  WISCOMBE, Brent

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61N5/062 ,  A61N2005/0645

摘要： Flexible probes are arranged to achieve a desired light distribution pattern for administering light therapy at a treatment site in a patient's body. The flexible probes (20, 20', 92) each include a flexible substrate on which are mounted light emitting devices (30) in spaced-apart array. An optically transparent, biocompatible envelope (36) encloses the flexible substrate and components mounted thereon. In one embodiment, a link (44) couples a pair of the flexible probes together in parallel alignment for insertion at the treatment site. Thereafter, the probes are moved relative to each other within the link to achieve the desired light distribution pattern. In another embodiment, the flexible probes include flexible leaders (70, 72) attached to their distal ends, which terminate in suture tabs (74) that can be affixed to tissue adjacent the treatment site. The flexible probes are inserted into the treatment site generally aligned in a compact bundle and then are arrayed in a grid and spaced apart using links (82) to secure them at points where the flexible probes cross each other transversely. A further embodiment includes a strip (90) having a longitudinal slot (96), that opens into a channel (98) for receiving balls (94) formed on the distal ends of the flexible probes. The strip maintains the flexible probes in a spaced-apart array. Finally, another embodiment includes a flexible sheet (100) on which the flexible probes are mounted using sutures (108) or staples (102) after the sheet and flexible probes have been introduced to the treatment site.

公开(公告)号：EP1009482A1

公开(公告)日：2000-06-21

申请号：EP97938521.8

申请日：1997-08-21

申请人： Light Sciences Limited Partnership

发明人： CHEN, James, C. ,  WISCOMBE, Brent

IPC分类号： A61N5/00

CPC分类号： A61N5/062 ,  A61N5/0601

摘要： This invention is a method and apparatus for administering intracorporeal photopheresis to blood flowing in a patient's body to destroy an undesirable component in the blood, where the undesirable component has absorbed a photoreactive agent having a characteristic light absorption wave band. The apparatus includes an implantable housing (100) that is adapted to be placed transcutaneously within a patient's body. An inlet (104), and outlet (102) for a fluid path (128) through the housing (100) are provided, and are coupled to a patient's circulator system so that they convey blood into, and out of, the housing (100). Light sources (110) disposed within the housing (100) (or externally disposed and coupled to the housing by optical fibers) emit light having a wave band substantially equal to the absorption wave band of the photoreactive agent. A portion of the fluid path (128) within the housing (100) is optically transparent so that blood is irradiated with light from the light source (110). The fluid path (128) can have one of several different configurations, including serpentine, planar coil, helical coil, and cross tubes coupling inlet and outlet header manifolds. The light source (110) can comprise light emitting diodes (LEDs) or other types of light sources, and may be coupled to the reactor through optical fibers. The power supply (800) for the light source (110) can be intracorporeal or extracorporeal.

摘要翻译： 本发明是一种用于对体内流动的血液进行体内光照去除以破坏血液中不需要的成分的方法和设备，其中不需要的成分吸收了具有特征光吸收波段的光反应剂。 该设备包括适于经皮放置在患者体内的可植入外壳（100）。 提供了用于穿过壳体（100）的流体路径（128）的入口（104）和出口（102），并且耦合到患者的循环器系统，使得它们将血液输送到壳体（100）中和从壳体 ）。 布置在外壳（100）内（或外部布置并通过光纤耦合到外壳）的光源（110）发射具有基本上等于光反应剂的吸收波段的波段的光。 壳体（100）内的流体路径（128）的一部分是光学透明的，使得血液被来自光源（110）的光照射。 流体路径（128）可以具有几种不同构造中的一种，包括蛇形，平面盘管，螺旋形盘管以及连接入口和出口集管歧管的横管。 光源（110）可以包括发光二极管（LED）或其他类型的光源，并且可以通过光纤耦合到反应器。 用于光源（110）的电源（800）可以是体内的或体外的。

公开(公告)号：EP0973441A1

公开(公告)日：2000-01-26

申请号：EP98914531.3

申请日：1998-04-06

申请人： Light Sciences Limited Partnership

发明人： CHEN, James, C. ,  WISCOMBE, Brent

IPC分类号： A61B5/05

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61N2005/0652 ,  A61N2005/0653 ,  G01R33/285 ,  H05K3/284 ,  H05K3/321 ,  H05K2201/10106 ,  H05K2201/10636 ,  H05K2203/1311 ,  Y02P70/611

摘要： An implantable probe (100) having a non-metallic insulating base (126), non-metallic conductive traces (104, 106) supported by the base (126), and a plurality of non-metallic light sources supported by the base (126) and coupled to the conductive traces (104, 106). The conductive traces (104, 106) and the light sources are fabricated from the conductive polymer, which does not cause any artifacts if the implantable probe (100) includes an enclosure (102) that is transparent and hermetically encloses the base (126), the pair of conductive traces (104, 106), and the light sources. At least a portion of the enclosure (102) is optically transparent, enabling light emitted by the light sources to illuminate an adjacent treatment site. The conductive traces (104, 106) and the base (126) are substantially flexible, enabling the probe (100) to advance within the body to the treatment site. A non-metallic receiver coil (200) implanted in a patient's body is energized by inductively coupling it to an external transmitter coil (220). The current from the receiver coil (200) is conveyed to the implantable probe (100) through non-metallic leads (112, 114).