公开(公告)号：EP2782573A1

公开(公告)日：2014-10-01

申请号：EP12813949.0

申请日：2012-11-22

申请人： Lipidart Kutató Fejleszto És Tanácsadó Kft.

发明人： FÜLÖP, Ferenc ,  VÍGH, László ,  TÖRÖK, Zsolt ,  PENKE, Botond ,  HORVÁTH, Ibolya ,  BALOGH, Gábor ,  BERNÁTH, Sándor ,  HUNYA, Ákos

IPC分类号： A61K31/4422 ,  C07D211/80 ,  A61P25/28 ,  A61P35/00 ,  A61P5/50 ,  A61P43/00 ,  A61P35/02 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P25/16 ,  A61K41/00

CPC分类号： A61F7/00 ,  A61K31/4422 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/475 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07D211/90 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04

摘要： The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein R1 is optionally substituted C6-24aryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulphur, and combinations thereof; R2 and R3 are independently hydrogen or C1-6alkyl group; R4 and R5 are independently hydrogen, C1-6alkyl group optionally substituted with amino, mono- or di(C1-6alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C1-6alkyl group or C1-6 alkoxy group; R6 is C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-6alkyl or arylC1-6alkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters and prodrugs thereof for use in the therapeutic or prophylactic treatment of a disorder mediated by heat shock proteins.