公开(公告)号：EP2340232A1

公开(公告)日：2011-07-06

申请号：EP09778524.0

申请日：2009-09-15

申请人： Lonza AG

发明人： HANSELMANN, Paul ,  KLEGRAF, Ellen ,  WENGER, Wolfgang

IPC分类号： C01C3/00

CPC分类号： C01C3/003

摘要： Process for removing hydrogen cyanide from ethanedinitrile by contacting hydrogen cyanide-containing ethanedinitrile with an organic reagent under formation of a covalent bond.

摘要翻译： 通过使含氰化氢的乙二腈与共价键形成的有机试剂接触，从乙二腈中除去氰化氢的方法。

公开(公告)号：EP1430018B1

公开(公告)日：2010-12-29

申请号：EP02767473.8

申请日：2002-09-04

申请人： Lonza AG

发明人： HANSELMANN, Paul ,  HILDBRAND, Stefan

IPC分类号： C07C209/48 ,  C07C279/14 ,  C07C237/02 ,  C07D239/20

CPC分类号： C07D233/64 ,  Y02P20/55

摘要： The invention relates to β-alanine amides of general formula (I), wherein: R1 represents hydrogen or C¿1-6? alkyl that is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, optionally substituted aryl or heteroaryl, and; R?2¿ represents hydrogen or R?1 and R2¿, together, form a group of formula -(CH¿2?)n-, wherein n is 3 or 4. Said β-alanine amides are produced without using an amino protective group by reacting the corresponding amine with a cyanoacetic ester in order to form an acetamide and by effecting a subsequent catalytic hydrogenation. The method is suited, in particular, for producing carcinine (β-alanyl-histamine, R?1 ¿= imidazol-4-ylmethyl, R2 = H), a naturally occurring pseudo dipeptide, which is used as an active ingredient having an antioxidative effect in medicaments and cosmetics.

公开(公告)号：EP1282589A2

公开(公告)日：2003-02-12

申请号：EP01945163.2

申请日：2001-05-18

申请人： Lonza AG

发明人： GLUFKE, Uta ,  HANSELMANN, Paul

IPC分类号： C07C45/40 ,  C07C49/12

CPC分类号： C07C45/65 ,  C07C45/40 ,  C07C45/75 ,  C07C49/12 ,  C07C49/203

摘要： The invention relates to a method for producing α-dicarbonyl compounds of formula (I), wherein R?1 and R2¿, independently of each other, mean C¿1-6?-alkyl. Said method is characterised in that an α,ß-unsaturated ketone of formula (II), wherein R?1 and R2¿ have the meaning above and R?3 and R4¿, independently of each other, mean hydrogen, C¿1-6?-alkyl or di-C1-6-alkylamino, is reacted with ozone and the resulting ozonide is treated reductively.

公开(公告)号：EP1208081A1

公开(公告)日：2002-05-29

申请号：EP00964050.9

申请日：2000-08-29

申请人： Lonza AG

发明人： HANSELMANN, Paul ,  HILDBRAND, Stefan

IPC分类号： C07C253/30 ,  C07C255/19

CPC分类号： C07C253/30 ,  C07C255/19

摘要： The invention relates to a method for producing cyanoacetic acid esters of general formula (I), wherein R represents an optionally substituted linear or branched C1-8 alkyl group or an aryl C1-4 alkyl group. According to said method, an alkoxy propionitrile of general formula (II), wherein R is defined as above, is oxidised to form the desired product in the presence of a catalyst, based on lead or on one of the transition metals, using oxygen or an oxygen-forming reagent.

公开(公告)号：EP1360171B1

公开(公告)日：2008-05-14

申请号：EP02714146.4

申请日：2002-02-05

申请人： Lonza AG

发明人： GMÜR, Martin ,  DAUM, Ulrich ,  HEYL-FRANK, Brigitta ,  HANSELMANN, Paul ,  FALCHETTO, Alessandro

IPC分类号： C07C261/02 ,  C08G73/06

CPC分类号： C07C261/02 ,  C08G73/0655 ,  H05K1/0346

摘要： The invention relates to prepolymer compositions on the basis of Novolac cyanates of the general formula (I), wherein n is a number of from 0 to 20 and the groups R are the same or different and represent hydrogen or methyl. The inventive compositions contain: 30 to 90 parts by weight of a prepolymer from Novolac cyanates (I) wherein R = hydrogen (Ia) and 10 to 70 parts by weight of Novolac cyanates (I) wherein R = methyl (Ib), and optionally highly dispersible silicon dioxides and/or particulate or fibrous fillers. The inventive compositions are solid at normal temperature and can be ground to flowable powders. They have an excellent stability when stored and are easy to process and especially suitable for use as the resin component in base materials for printed circuits and resin-bound abrasive products.

公开(公告)号：EP1250316B1

公开(公告)日：2004-12-29

申请号：EP01913765.2

申请日：2001-01-24

申请人： Lonza AG

发明人： HANSELMANN, Paul ,  HILDBRAND, Stefan ,  STERREN, Etienne

IPC分类号： C07C259/06 ,  C07C259/10 ,  C07D307/68

CPC分类号： C07D307/68 ,  C07C259/06 ,  C07C259/10

摘要： The invention relates to a method for producing N -alkoxy- N -alkylamides of general formula (I), wherein R represents C1-10 alkyl, cyclo-C5-7 alkyl, cyclo-C5-7 alkenyl, C2-10 alkenyl, aryl, aryl C1-3 alkyl, heteroaryl, heteroaryl C1-3 alkyl or heterocyclyl; and R2 represents C1-6 alkyl. The inventive compounds are characterized in that an ester of general formula (II): R COOR , wherein R has the above-mentioned meaning, and R represents C1-6 alkyl, 4-nitrophenyl, 2,4-dinitrophenyl, succinimido or benzotriazole-1-yl, is reacted with hydroxylamine, a hydroxylamine derivative or with a hydroxylammonium salt, and the reaction product is alkylated in the presence of a phase transfer catalyst.

公开(公告)号：EP1140806B1

公开(公告)日：2003-05-28

申请号：EP00901065.3

申请日：2000-01-05

申请人： Lonza AG

发明人： HANSELMANN, Paul ,  HILDEBRAND, Stefan

IPC分类号： C07C281/18 ,  C07C277/08

CPC分类号： C07C281/18 ,  C07C277/08

公开(公告)号：EP1259479A1

公开(公告)日：2002-11-27

申请号：EP01933657.7

申请日：2001-03-01

申请人： Lonza AG

发明人： GLUFKE, Uta ,  HANSELMANN, Paul

IPC分类号： C07C235/80

CPC分类号： C07C235/80

摘要： The invention relates to novel acetoacetylated diamines and polyamines and to a method for the production thereof. The acetoacetylated diamines and polyamines are compounds of formula (I), wherein R?1 and R2¿, independent of one another, represent hydrogen or C¿1-6? alkyl, and A represents C3-8 cycloalkanediyl or a group of formula (II): -(CR?3R4)¿p-[NR-(CR5R6)q]r .

公开(公告)号：EP1680391A1

公开(公告)日：2006-07-19

申请号：EP04817266.2

申请日：2004-10-22

申请人： Lonza AG

发明人： HANSELMANN, Paul ,  WENGER, Wolfgang

IPC分类号： C07C67/03 ,  C07D309/38 ,  C07C69/738 ,  C07C69/716

CPC分类号： C07C69/738 ,  C07C67/03 ,  C07D309/38 ,  C07C69/716

摘要： The invention relates to a method for the production of 6,6,6-trihalo-3,5-dioxohexanic acid esters of formula (I) in addition to the enols thereof and E and Z isomers, wherein X independently represents fluorine, chlorine or bromine and R1 represents alkyl, cycloalkyl, aryl or aralkyl. The invention also relates to a method for the production of enol ethers of formula (Ib) and the enols thereof (E and Z isomers) wherein X and R1 have the above-mentioned meaning.

摘要翻译： 本发明涉及除了其烯醇和E和Z异构体之外还生产式（I）的6,6,6-三卤代-3,5-二氧代己酸酯的方法，其中X独立地代表氟，氯或 溴并且R 1表示烷基，环烷基，芳基或芳烷基。 本发明还涉及制备式（Ib）的烯醇醚及其烯醇（E和Z异构体）的方法，其中X和R1具有上述含义。

公开(公告)号：EP1252134A1

公开(公告)日：2002-10-30

申请号：EP01913783.5

申请日：2001-02-02

申请人： Lonza AG

发明人： GLUFKE, Uta ,  HANSELMANN, Paul

IPC分类号： C07C231/04 ,  C07C237/16 ,  C07C237/10 ,  C07C231/12

CPC分类号： C07C237/16 ,  C07C231/04 ,  C07C231/12 ,  C07C237/10

摘要： Novel acetoacetylated aromatic amine compounds are claimed. - Novel acetoacetylated aromatic amine compounds (I) are of formula (1). - R1, R2 = OH, 1-6C alkyl, 1-6C alkoxy, halogen, phenyl or phenoxy; - R3 = H or 1-6C alkyl; - m = 0-4; - n = 0-5. - Independent claims are included for: - (i) a process for the production of the compounds (I) (R3=1-6C alkyl) by reaction of diketene with an N-phenyl-p-phenylenediamine of formula (2) in the presence of 3-40 % acetic acid at 20-100 (60-70) degreesC; - (ii) new unsaturated amino-ketone compounds (II) of formula (3) prepared by reaction of the amine compound (I) with ammonia; and - (iii) new amino-ketone compounds (III) of formula (4) prepared by catalytic hydrogenation of (II).