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公开(公告)号：EP4243852A1
公开(公告)日：2023-09-20
申请号：EP21892863.8
申请日：2021-11-12
申请人： Ludwig Institute for Cancer Research Ltd , Centre Hospitalier Universitaire Vaudois , University of Lausanne
发明人： COUKOS, George , IRVING, Melita , ZOETE, Vincent
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2.发明公开
公开(公告)号：EP3940063A2
公开(公告)日：2022-01-19
申请号：EP20757209.0
申请日：2020-03-09
申请人： Centro de Inmunologia Molecular , Ludwig Institute for Cancer Research Ltd , Centre Hospitalier Universitaire Vaudois , University of Lausanne
发明人： LEÓN MONZÓN, Kalet , MONTALVO BEREAU, Galia Magela , COUKOS, George , IRVING, Melita , CRIBIOLI, Elisabetta , ORTIZ MIRANDA, Yaquelín , CORRIA OSORIO, Ángel de Jesús
IPC分类号： C12N5/0783 , A61K39/00 , C07K14/55
摘要： The present invention describes a method for obtaining lymphoid cells having a desired phenotype for adoptive transfer therapies useful for the treatment of cancer. Especially, this invention is related to strategies for inducing preferential signaling through the intermediate affinity IL-2 receptor in order to expand the cells with a desired central memory phenotype. The method of the present invention is useful for obtaining tumor-infiltrating lymphocytes, TCR or chimeric antigen receptor engineered T cells for the treatment of cancer.
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公开(公告)号：EP4448776A1
公开(公告)日：2024-10-23
申请号：EP22850940.2
申请日：2022-12-15
申请人： Ludwig Institute for Cancer Research Ltd , University of Lausanne , Centre Hospitalier Universitaire Vaudois
IPC分类号： C12N15/86 , C07K14/725 , C12N5/078
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公开(公告)号：EP3406733A1
公开(公告)日：2018-11-28
申请号：EP17172639.1
申请日：2017-05-24
申请人： SIB Swiss Institute of Bioinformatics , Centre Hospitalier Universitaire Vaudois (CHUV) , Université de Lausanne , Ludwig Institute for Cancer Research Ltd
发明人： MICHIELIN, Olivier , ZOETE, Vincent , COUKOS, George , IRVING, Melita , DILEK, Nahzli , REICHENBACH, Patrick , ASCENCAO, Kelly
CPC分类号： C12Q1/485 , A61K38/43 , C12N9/1205
摘要： The present invention relates to methods of designing kinase mutants for reprogramming the sensitivity of a target kinase to some specific inhibitors, methods of reprogramming the sensitivity of a target kinase to some specific inhibitors, wherein those kinase inhibitors have little or no affinity for the wild-type target kinase, vectors or cells expressing said mutated kinases, composition and uses thereof for the prevention and/or treatment of a disease or disorder, in particular cancer.
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公开(公告)号：EP3630998A1
公开(公告)日：2020-04-08
申请号：EP18727003.8
申请日：2018-05-24
申请人： SIB Swiss Institute of Bioinformatics , Centre Hospitalier Universitaire Vaudois (CHUV) , Université de Lausanne , Ludwig Institute for Cancer Research Ltd
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公开(公告)号：EP4058035A1
公开(公告)日：2022-09-21
申请号：EP20888482.5
申请日：2020-11-13
IPC分类号： A61K35/17 , A61P35/00 , C12N5/078 , C12N5/0783
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公开(公告)号：EP3774866A1
公开(公告)日：2021-02-17
申请号：EP19720071.0
申请日：2019-04-12
发明人： COUKOS, George , IRVING, Melita , CORREIA, Bruno , GAINZA-CIRAUQUI, Pablo , GIORDANO ATTIANESE, Greta, Maria, Paola
IPC分类号： C07K14/705 , C07K14/725 , C07K16/30
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公开(公告)号：EP3941939A2
公开(公告)日：2022-01-26
申请号：EP20721721.7
申请日：2020-03-17
IPC分类号： C07K14/725 , G01N33/50
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