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公开(公告)号：EP2888228A1
公开(公告)日：2015-07-01
申请号：EP13756096.7
申请日：2013-08-27
申请人： Ludwig-Maximilians-Universität München , Maastricht University , Academisch Ziekenhuis Maastricht
IPC分类号： C07C251/24 , C07C251/26 , C07D307/52 , C07D333/22 , A61P19/00 , A61P17/00
CPC分类号： A61K31/381 , A61K31/137 , A61K31/341 , C07C251/24 , C07C251/26 , C07D307/52 , C07D333/22
摘要： The present invention relates to compounds acting as selective inhibitors of CD40-TRAF6 interaction, their use as medicaments and their use in the treatment of (chronic) inflammatory diseases. The present invention also relates to pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及作为CD40-TRAF6相互作用的选择性抑制剂的化合物，它们作为药物的用途及其在治疗（慢性）炎性疾病中的用途。 本发明还涉及包含这些化合物的药物组合物。
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公开(公告)号：EP2888228B1
公开(公告)日：2019-04-24
申请号：EP13756096.7
申请日：2013-08-27
申请人： Ludwig-Maximilians-Universität München , Maastricht University , Academisch Ziekenhuis Maastricht
IPC分类号： C07C251/24 , C07C251/26 , C07D307/52 , C07D333/22 , A61P19/00 , A61P17/00
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公开(公告)号：EP3889262A1
公开(公告)日：2021-10-06
申请号：EP21165535.2
申请日：2021-03-29
IPC分类号： C12N15/113
摘要： The present invention relates to a nucleic acid molecule comprising or consisting of (a) the nucleic acid sequence of SEQ ID NO: 1, (b) a nucleic acid sequence being at least 80%, preferably at least 90% and most preferably at least 95% identical to SEQ ID NO: 1, (c) a fragment of the nucleic acid sequence of (a) or (b), wherein said fragment comprises at least 15 nucleotides, preferably at least 17 nucleotides and most preferably at least 19 nucleotides, (d) the nucleic acid sequence or any one of (a) to (c), wherein U is replaced by T, (e) a vector expressing the nucleic acid sequence of any one of (a) to (d), and/or (f) a host comprising the vector of (e) for use in the prevention and/or treatment of disease-related apoptosis.
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