公开(公告)号：EP2027250A2

公开(公告)日：2009-02-25

申请号：EP07797660.3

申请日：2007-05-22

Applicant: Lumencor, Inc.

Inventor： JAFFE, Claudia B. ,  JAFFE, Steven M. ,  JONES, Michieal L.

IPC: C12M1/34

CPC classification number: G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

公开(公告)号：EP2697646B1

公开(公告)日：2016-02-10

申请号：EP11855826.1

申请日：2011-12-02

Applicant: Lumencor, Inc.

Inventor： JAFFE, Claudia B. ,  JAFFE, Steven M. ,  LARSEN, David

IPC: G01N33/52 ,  G01N21/64 ,  G01N33/48

CPC classification number: G01N21/645 ,  F21V23/0457 ,  G01J1/4257 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2201/061 ,  H05B33/0869

Abstract: A system and method for metered dosage illumination in a bioanalysis or other system includes an illumination system or subsystem that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can be precisely controlled to generate a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. The system and method is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.

公开(公告)号：EP2697646A1

公开(公告)日：2014-02-19

申请号：EP11855826.1

申请日：2011-12-02

Applicant: Lumencor, Inc.

Inventor： JAFFE, Claudia B. ,  JAFFE, Steven M. ,  LARSEN, David

IPC: G01N33/52 ,  G01N21/64 ,  G01N33/48

CPC classification number: G01N21/645 ,  F21V23/0457 ,  G01J1/4257 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2201/061 ,  H05B33/0869

Abstract: A system and method for metered dosage illumination in a bioanalysis or other system includes an illumination system or subsystem that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can be precisely controlled to generate a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. The system and method is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.

Abstract translation: 用于生物分析或其他系统中的计量剂量照射的系统和方法包括照射系统或子系统，其可以在测量快速生物活性所需的短曝光时间内提供优化量的激发光。 可以精确测量光量以提供定量结果。 可以精确控制光通量以产生规定的最小光量，以便减少荧光粉和样品的不利照明效果。 该系统和方法在任何质量控制，分析或基于评估的环境中特别有用。 典型的研究和开发应用可以包括质量控制，仪器校准和光输出标准化; 而临床和诊断应用可以包括临床监测，生物测定校准和控制诊断，治疗和或治疗评估。