公开(公告)号：EP1054632A1

公开(公告)日：2000-11-29

申请号：EP98909999.9

申请日：1998-02-13

申请人： Lumend, Inc. ,  Selmon, Matthew R. ,  Hansen, Gerald F. ,  Milo, Charles F.

发明人： SELMON, Matthew, R. ,  HANSEN, Gerald ,  MILO, Charles, F.

IPC分类号： A61B17/22 ,  A61M29/00 ,  A61B5/00

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B17/22 ,  A61B17/320725 ,  A61B18/245 ,  A61B2017/003 ,  A61B2017/22044 ,  A61B2017/22069 ,  A61B2017/320044 ,  A61B2090/3614 ,  A61B2217/005 ,  A61M29/00 ,  A61M29/02

摘要： Disclosed herein is an intravascular catheter system for crossing a severe or total arterial occlusion; particularly, a steerable intravascular catheter providing a working element and the optical guidance thereof in crossing an occlusion. Also disclosed is a method of crossing a severe or total arterial occlusion with a steerable catheter working element under optical guidance.

公开(公告)号：EP1047344A1

公开(公告)日：2000-11-02

申请号：EP98963257.5

申请日：1998-12-18

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  HILL, Richard, E. ,  CO, Fred, H. ,  MILO, Charles, F. ,  FRENCH, Ronald, G.

IPC分类号： A61B17/22

CPC分类号： A61B17/3207 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/003 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22095 ,  A61B2018/00392 ,  A61B2090/3925 ,  A61M25/01 ,  A61M2025/0096

摘要： Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal the occlusion and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn and the guidewire is available for introduction of other interventional and diagnostic catheters.

公开(公告)号：EP1119387A2

公开(公告)日：2001-08-01

申请号：EP99942548.1

申请日：1999-08-27

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  MILO, Charles, F. ,  CO, Fred ,  CAMPELLO, Mark ,  FRENCH, Ronald ,  AGUILAR, Amiel

IPC分类号： A61M25/01

CPC分类号： A61B17/3207 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/003 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22095 ,  A61B2018/00392 ,  A61B2090/3925 ,  A61M25/01 ,  A61M2025/018 ,  A61M2025/0197

摘要： Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The wire may be advanced to a point distal to the occlusion, and thereafter deflected back into the blood vesel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. The deflecting catheter may include a flapper valve assembly or preformed actuator wire for redirecting the guidewire. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn, and the guidewire may be available for introduction of other inverventional and diagnostic catheters for performing procedures such as stenting.

公开(公告)号：EP1119387B1

公开(公告)日：2007-02-14

申请号：EP99942548.1

申请日：1999-08-27

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  MILO, Charles, F. ,  CO, Fred ,  CAMPELLO, Mark ,  FRENCH, Ronald ,  AGUILAR, Amiel

IPC分类号： A61M25/01

CPC分类号： A61B17/3207 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/003 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22095 ,  A61B2018/00392 ,  A61B2090/3925 ,  A61M25/01 ,  A61M2025/018 ,  A61M2025/0197

摘要： Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The wire may be advanced to a point distal to the occlusion, and thereafter deflected back into the blood vesel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. The deflecting catheter may include a flapper valve assembly or preformed actuator wire for redirecting the guidewire. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn, and the guidewire may be available for introduction of other inverventional and diagnostic catheters for performing procedures such as stenting.

公开(公告)号：EP1112103B1

公开(公告)日：2006-01-04

申请号：EP99968634.8

申请日：1999-08-27

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  MILO, Charles, F. ,  WYNNE, Robert, L. ,  PAL, Suresh, S. ,  DELL, Kent, D. ,  GRESL, Charles ,  HANSEN, Gerald ,  HILL, E. Richard

IPC分类号： A61M29/00 ,  A61B17/12 ,  A61M25/00

CPC分类号： A61M29/02 ,  A61B17/22 ,  A61B2017/320044 ,  A61B2017/320741

摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.

公开(公告)号：EP1054704A1

公开(公告)日：2000-11-29

申请号：EP98912883.0

申请日：1998-02-13

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  HANSEN, Gerald ,  MILO, Charles, F.

IPC分类号： A61M29/00 ,  A61B17/22

CPC分类号： A61M29/02 ,  A61B17/22031 ,  A61B2017/00845 ,  A61B2017/22069 ,  A61B2017/2933 ,  A61B2017/2937 ,  A61B2017/320044 ,  A61B2017/320741

摘要： Disclosed herein is a blunt end assembly including a catheter and a blunt end member. The blunt end member includes jaw sections which have a first closed position for locating the blunt end member at the site of the occlusion within the native lumen of the blood vessel and a second open position wherein the jaw sections are able to press against the interior walls of the lumen adjacent the occlusion. The assembly includes an actuation member for moving the jaw sections from the closed to the open positions repeatedly resulting in a fracturing of the occlusion. A guide wire may be thread through an internal opening in the catheter and the blunt end member and after fracturing, across the occlusion.

公开(公告)号：EP1054704B1

公开(公告)日：2008-08-27

申请号：EP98912883.0

申请日：1998-02-13

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  HANSEN, Gerald ,  MILO, Charles, F.

IPC分类号： A61M29/00 ,  A61B17/22

CPC分类号： A61M29/02 ,  A61B17/22031 ,  A61B2017/00845 ,  A61B2017/22069 ,  A61B2017/2933 ,  A61B2017/2937 ,  A61B2017/320044 ,  A61B2017/320741

摘要： Disclosed herein is a blunt end assembly including a catheter and a blunt end member. The blunt end member includes jaw sections which have a first closed position for locating the blunt end member at the site of the occlusion within the native lumen of the blood vessel and a second open position wherein the jaw sections are able to press against the interior walls of the lumen adjacent the occlusion. The assembly includes an actuation member for moving the jaw sections from the closed to the open positions repeatedly resulting in a fracturing of the occlusion. A guide wire may be thread through an internal opening in the catheter and the blunt end member and after fracturing, across the occlusion.

公开(公告)号：EP1112103A2

公开(公告)日：2001-07-04

申请号：EP99968634.8

申请日：1999-08-27

申请人： Lumend, Inc.

发明人： SELMON, Matthew, R. ,  MILO, Charles, F. ,  WYNNE, Robert, L. ,  PAL, Suresh, S. ,  DELL, Kent, D. ,  GRESL, Charles ,  HANSEN, Gerald ,  HILL, E. Richard

IPC分类号： A61M29/00

CPC分类号： A61M29/02 ,  A61B17/22 ,  A61B2017/320044 ,  A61B2017/320741

摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.

公开(公告)号：EP1030705A2

公开(公告)日：2000-08-30

申请号：EP98956589.0

申请日：1998-11-04

申请人： Lumend, Inc.

发明人： MILO, Charles, F.

IPC分类号： A61M25/01 ,  A61B17/22

CPC分类号： A61B17/22012 ,  A61B17/320758 ,  A61M25/0105 ,  A61M25/0116 ,  A61M25/09041

摘要： A guidewire or a catheter for crossing vascular occlusions comprises a shaft having a proximal end a distal end, and a drive member having a proximal and a distal end, the drive member being rotatably disposed within and along a longitudinal axis of the guidewire shaft. An actuator is connected to the proximal end of the drive member, the actuator imparting a rotation to the drive member. An asymmetrical rotating tip is attached to the distal end of the drive member and driven in rotation about the longitudinal axis of the shaft by the drive member. The rotating tip may include a protruding portion that projects from a plane defined by an outer surface of the guidewire shaft to render the rotating tip asymmetrical with respect to the longitudinal axis of the shaft. The protruding portion creates a volume of revolution as the asymmetrical tip rotates, which facilitates crossing a vascular occlusion by displacing and exerting pressure on stenotic material causing the occlusion. Alternatively, the rotating tip may be symmetrical. A coupling member may be attached to the distal end of the shaft and may include a distal angled surface. When the tip includes a mating angled surface, rotation of the drive member causes the tip to undergo both a reciprocal and a rotational motion along and about the longitudinal axis of the shaft.