专利检索 ap:("Luoxin Pharmaceutical (Shanghai) Co., Ltd." OR "Shandong Luoxin Pharmaceutical Group Stock Co., Ltd." OR "Medshine Discovery Inc.") AND inv:"WANG, Tie-Lin" 第 1 页

1.

发明公开
IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF 审中-公开

公开(公告)号：EP3766883A1

公开(公告)日：2021-01-20

申请号：EP19767751.1

申请日：2019-03-12

申请人： Luoxin Pharmaceutical (Shanghai) Co., Ltd. , Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. , Medshine Discovery Inc.

发明人： CHEN, Kevin X , YAN, Xiaobing , HUANG, Jianglei , NIE, Yuekun , HU, Guoping , LI, Jian , CHEN, Shuhui , DONG, Jiaqiang , WANG, Tie-Lin

IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00 , A61P31/04 , A61P31/12

摘要： Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

2.

发明授权
INDOLO-SUBSTITUTED-PIPERIDINE COMPOUNDS AS ESTROGEN RECEPTOR DEGRADING AGENT 有权

公开(公告)号：EP3434668B1

公开(公告)日：2020-08-26

申请号：EP17769483.3

申请日：2017-03-24

申请人： Luoxin Pharmaceutical (Shanghai) Co., Ltd. , Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

发明人： LU, Jianyu , DING, Charles Z. , HU, Lihong , HE, Huijun , CHEN, Shuhui , DONG, Jiaqiang , WANG, Tie-Lin

IPC分类号： C07D209/18 , C07D409/06 , C07D403/12 , A61K31/404 , A61P35/00

3.

发明公开
SALT FORM OF ESTROGEN RECEPTOR DOWNREGULATOR, CRYSTALLINE FORM THEREOF, AND PREPARATION METHOD THEREFOR 审中-公开

公开(公告)号：EP3889136A1

公开(公告)日：2021-10-06

申请号：EP19888746.5

申请日：2019-10-17

申请人： Luoxin Pharmaceutical (Shanghai) Co., Ltd. , Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

发明人： HE, Huijun , SHI, Shenyi , LU, Jianyu , DING, Charles Z. , HU, Lihong , SHI, Bin , YANG, Wenqian , DONG, Jiaqiang , WANG, Tie-Lin

IPC分类号： C07D209/18 , A61K31/404 , A61P35/00

摘要： Provided are a salt form of an estrogen receptor down-regulator, a crystalline form thereof, and a preparation method therefor.

4.

发明公开
QUINAZOLINONE COMPOUND AND APPLICATION THEREOF 审中-公开

公开(公告)号：EP3712143A1

公开(公告)日：2020-09-23

申请号：EP18876913.7

申请日：2018-11-12

申请人： Luoxin Pharmaceutical (Shanghai) Co., Ltd. , Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

发明人： WU, Chengde , HUANG, Jingjie , YU, Tao , DONG, Jiaqiang , WANG, Tie-Lin , LI, Jie , LI, Jian , CHEN, Shuhui

IPC分类号： C07D401/04 , C07D401/14 , C07D417/14 , C07D409/14 , C07D405/14 , A61K31/517 , A61P35/00

摘要： The present invention relates to a series of quinazolinone compounds and applications thereof as PI3Kα inhibitors. In particular, the present invention relates to a compound shown in formula (I) and a tautomer or pharmaceutically acceptable salt thereof.