公开(公告)号：EP0693904A4

公开(公告)日：1998-05-06

申请号：EP94914132

申请日：1994-04-12

申请人： MALLINCKRODT MEDICAL INC

发明人： DEUTSCH EDWARD A ,  DEUTSCH KAREN F ,  NOSCO DENNIS L ,  RALSTON WILLIAM H ,  WHITE DAVID H ,  WILKING JANET B ,  WOLFANGEL ROBERT G ,  WOULFE STEVEN R

IPC分类号： A61B5/055 ,  A61B8/00 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61K51/00 ,  A61K51/12 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38 ,  G01R33/28 ,  A61B8/08 ,  A61K33/42 ,  C01B25/10 ,  C01F17/00

CPC分类号： A61K51/1241 ,  A61B90/39 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61K47/6923 ,  A61K49/0414 ,  A61K49/1818 ,  A61K49/1842 ,  A61K49/1878 ,  A61K49/1881 ,  A61K49/225 ,  G01R33/281 ,  Y10S977/722 ,  Y10S977/881 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

公开(公告)号：EP0802919A4

公开(公告)日：1999-08-18

申请号：EP94923179

申请日：1994-06-03

申请人： MALLINCKRODT MEDICAL INC

发明人： DEROSCH MARK A ,  DEUTSCH EDWARD A ,  DEUTSCH KAREN F

IPC分类号： A61K51/00 ,  A61K51/04 ,  A61K51/12 ,  C07F13/00

CPC分类号： A61K51/0489 ,  A61K51/12 ,  C07F13/005

公开(公告)号：EP0692978A4

公开(公告)日：1998-05-06

申请号：EP94912332

申请日：1994-03-29

申请人： MALLINCKRODT MEDICAL INC

发明人： BRODACK JAMES W ,  DEROSCH MARK A ,  DEUTSCH EDWARD A ,  DEUTSCH KAREN F ,  DYSZLEWSKI MARY MARMION

IPC分类号： A61K51/00 ,  A61K51/04 ,  A61K51/12

CPC分类号： A61K51/1282 ,  A61K51/0476 ,  A61K2123/00

摘要： The present invention relates to novel radiopharmaceutical imaging agents having non-stannous reductants. Metallic compounds, such as Cu(I), Cu(II), Co(II), Fe(II), Sn(O), Zr(O), Cr(II) and Zn(O), will act to effectively reduce radionuclide containing solutions. Several non-metallic compounds, such as acids in general, dithionite, formamidine, formamadine sulfinic acid, phosphite, hypophosphite, dithiotreitol, hydrochloric acid, and borohydric acid may also be used to reduce radionuclide containing solutions. Moreover, it has been discovered that several agents, such as phosphines, sulfhydryl compounds, phosphites, thiols, thioethers, borates, borocyano groups, ascorbates and gentisates efficiently reduce radionuclide containing solutions and complex with the radionuclide at the same time. The present invention also relates to kits for forming radiopharmaceutical imaging agents, such kits including non-stannous reducing agents.

摘要翻译： 本发明涉及具有非亚锡还原剂的新型放射性药物显像剂。 本发明还涉及用于形成放射性药物成像剂的试剂盒，所述试剂盒包括非亚锡还原剂。