公开(公告)号：EP3542808A3

公开(公告)日：2019-11-20

申请号：EP19150368.9

申请日：2014-04-11

申请人： MANGOGEN PHARMA INC.

发明人： PRAKASH, Satya ,  PAUL, Arghya ,  SHUM-TIM, Dominique

IPC分类号： A61K35/76 ,  A61K31/7088 ,  A61K38/18 ,  A61K47/34 ,  A61K9/14 ,  A61L31/08 ,  A61L31/14 ,  A61P17/02 ,  C12N11/08 ,  C12N15/866 ,  C12N7/01

摘要： The present invention provides viral microparticles comprising genetically-engineered baculovirus embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally incombination with a medical implant such as vascular stent platforms). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound.

公开(公告)号：EP2983682A1

公开(公告)日：2016-02-17

申请号：EP14783183.8

申请日：2014-04-11

申请人： MANGOGEN PHARMA INC.

发明人： PRAKASH, Satya ,  PAUL, Arghya ,  SHUM-TIM, Dominique

IPC分类号： A61K35/76 ,  A61K31/7088 ,  A61K38/18 ,  A61K47/34 ,  A61K9/14 ,  A61L31/08 ,  A61L31/14 ,  A61P17/02 ,  C12N11/08 ,  C12N15/866 ,  C12N7/01

CPC分类号： A61K35/76 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/19 ,  A61K38/36 ,  A61K38/363 ,  A61K48/00 ,  A61L31/10 ,  A61L31/125 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/622 ,  A61L2430/34 ,  C12N7/00 ,  C12N2710/14032 ,  C12N2710/14043 ,  C12N2710/14143

摘要： The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound.

摘要翻译： 本发明提供的病毒微粒，包括基因工程改造的杆状病毒（至少部分地）嵌入在用于局部递送治疗性核酸分子的脊椎动物个体的细胞中的聚合物基体（任选与医疗植入物的组合：如血管支架平台 ）。 病毒微粒的爱宣传片婷伤口愈合以及血管的修复是特别有用的，防止病理性疤痕。 所以提供了可用于制备病毒微粒过程中，药物组合物包含病毒微粒以及支撑件，其包括用于在伤口或在伤口附近的定位病毒微粒的病毒微粒。