专利检索 ap:("MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH") AND inv:"LUST, John, A." 第 1 页

1.

发明公开
IL-1 INHIBITION FOR MYELOMA AND RELATED DISORDERS 审中-公开
标题翻译： IL-1抑制骨髓瘤AGAINST和相关疾病

公开(公告)号：EP1385989A2

公开(公告)日：2004-02-04

申请号：EP02731168.7

申请日：2002-03-27

申请人： MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH

发明人： DONOVAN, Kathleen, A. , LUST, John, A.

IPC分类号： C12Q1/02

CPC分类号： G01N33/57407 , A61K38/1793 , A61K38/20 , A61K2039/505 , C07K16/245 , G01N33/6869 , G01N2333/5412 , G01N2333/545

摘要： Diagnostic methods for the detection of multiple myeloma (MM) and the identification of high-risk patients with multiple myeloma-related plasma proliferative disorders, such as monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM), likely to progress to active MM are described. The diagnosis is based on the determination of concentrations of bioactive IL-1ß produced by bone marrow plasma cells of these patients. Also described are therapeutic methods for the treatment of MM and for the chemoprevention of the progression from disorders such as MGUS and SMM to active MM, involving the administration of inhibitors of IL-1ß.

2.

发明公开
USE OF GENETICALLY ENGINEERED ANTIBODIES TO CD38 TO TREAT MULTIPLE MYELOMA 审中-公开
标题翻译：使用遗传方式设计抗体CD38多发性骨髓瘤的治疗

公开(公告)号：EP1085882A2

公开(公告)日：2001-03-28

申请号：EP99927226.3

申请日：1999-06-04

申请人： MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH

发明人： LUST, John, A. , DONOVAN, Kathleen, A.

IPC分类号： A61K31/70 , A61K38/16 , C07K19/00 , C12N15/62 , C07K14/46 , A61K39/395

CPC分类号： C07K16/2896 , A61K38/00 , A61K39/395 , A61K47/6849 , A61K2039/505 , C07K14/46 , C07K2317/24 , C07K2317/622 , C07K2319/00 , A61K2300/00

摘要： A fusion polypeptide comprising an antibody or a fragment thereof is provided. The fusion polypeptide is useful in a therapeutic composition to treat multiple myeloma.