公开(公告)号：EP1414425A1

公开(公告)日：2004-05-06

申请号：EP02761085.6

申请日：2002-07-12

申请人： MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH ,  Virginia Tech Intellectual Properties, Inc.

发明人： RICHELSON, Elliott ,  CARLIER, Paul, R.

IPC分类号： A61K31/135 ,  C07C215/00

CPC分类号： C07C215/28 ,  A61K31/137 ,  A61K31/138 ,  A61K45/06 ,  C07C215/30 ,  A61K2300/00

摘要： The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake.

公开(公告)号：EP1042349A1

公开(公告)日：2000-10-11

申请号：EP98953610.7

申请日：1998-10-16

申请人： MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH

发明人： RICHELSON, Elliott ,  TYLER, Beth, Marie ,  McCORMICK, Daniel, J. ,  CUSACK, Bernadette, Marie ,  HOSHALL, Clark, V. ,  DOUGLAS, Christopher, Lee ,  JANSEN, Karen

IPC分类号： C07H21/04 ,  A61K48/00 ,  C12Q1/68

CPC分类号： C07K14/003 ,  A61K38/00 ,  A61K2123/00 ,  C12N15/1138 ,  C12N2310/3181

摘要： The invention provides methods of treating living cells with PNA oligomers such that the oligomers cross a biological barrier and engender a biological response. The invention provides methods for screening potential PNA oligomers for the ability to engender a sequence specific biological response. The invention also provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.

公开(公告)号：EP1067950A1

公开(公告)日：2001-01-17

申请号：EP99916562.4

申请日：1999-04-09

申请人： MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH

发明人： RICHELSON, Elliott ,  CUSACK, Bernadette, Marie ,  PANG, Yuan-Ping ,  McCORMICK, Daniel, J. ,  FAUQ, Abdul ,  TYLER, Beth, Marie ,  BOULES, Mona

IPC分类号： A61K38/02 ,  A61K38/10 ,  C07D209/08 ,  C07K2/00 ,  C07K7/08 ,  C12Q1/37

CPC分类号： C07K7/083 ,  A61K38/00 ,  C07D209/08 ,  C07K7/14 ,  C07K7/18 ,  C07K14/70 ,  C07K14/702

摘要： The invention provides a novel amino acid, neo-tryptophan as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.