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1.发明授权MITOCHONDRIAL DNA DELETION BETWEEN ABOUT RESIDUES 12317-16254 FOR USE IN THE DETECTION OF CANCER 有权用于检测癌症的残留物12317-16254之间的线粒体DNA缺失
公开(公告)号：EP2220252B1
公开(公告)日：2018-03-14
申请号：EP08846547.1
申请日：2008-11-10
发明人： PARR, Ryan , CREED, Jennifer , ROBINSON, Kerry , MAGGRAH, Andrea , MAKI, Katrina , DAKUBO, Gabriel , REGULY, Brian , HARBOTTLE, Andrew , ALEXANDER, Jude
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
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