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1.发明授权ABERRANT MITOCHONDRIAL DNA, ASSOCIATED FUSION TRANSCRIPTS AND HYBRIDIZATION PROBES THEREFOR 有权异常线粒体DNA相关联的融合转录物和杂交探针THEREFOR
公开(公告)号：EP2274426B1
公开(公告)日：2016-11-16
申请号：EP09725638.2
申请日：2009-03-27
发明人： PARR, Ryan , REGULY, Brian , DAKUBO, Gabriel , CREED, Jennifer , ROBINSON, Kerry
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/158
摘要： The present invention provides novel mitochondrial fusion transcripts and the parent mutated mtDNA molecules that are useful for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
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2.发明授权MITOCHONDRIAL DNA DELETION BETWEEN ABOUT RESIDUES 12317-16254 FOR USE IN THE DETECTION OF CANCER 有权用于检测癌症的残留物12317-16254之间的线粒体DNA缺失
公开(公告)号：EP2220252B1
公开(公告)日：2018-03-14
申请号：EP08846547.1
申请日：2008-11-10
发明人： PARR, Ryan , CREED, Jennifer , ROBINSON, Kerry , MAGGRAH, Andrea , MAKI, Katrina , DAKUBO, Gabriel , REGULY, Brian , HARBOTTLE, Andrew , ALEXANDER, Jude
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
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公开(公告)号：EP2411522B1
公开(公告)日：2017-09-06
申请号：EP10761136.0
申请日：2010-03-29
发明人： PARR, Ryan , DAKUBO, Gabriel , HARBOTTLE, Andrew , REGULY, Brian , CREED, Jennifer , ROBINSON, Kerry , KLEIN, Daniel
IPC分类号： C12N15/12 , C07H21/00 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/68 , C07K19/00 , C12N15/62
CPC分类号： C07K14/4748 , C12N9/0036 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Y106/00 , G01N33/57484
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4.发明公开
公开(公告)号：EP3305902A1
公开(公告)日：2018-04-11
申请号：EP17192852.6
申请日：2011-03-01
发明人： HARBOTTLE, Andrew , DAKUBO, Gabriel , PARR, Ryan , CREED, Jennifer , REGULY, Brian , ROBINSON, Kerry
CPC分类号： C12Q1/6883 , C07K14/80 , C07K2319/00 , C12N9/0036 , C12N9/0053 , C12N9/12 , C12N9/14 , C12N15/62 , C12Q2600/148 , C12Q2600/156 , C12Y106/99003 , C12Y109/03001 , C12Y207/10001 , C12Y306/01003
摘要： The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products.
摘要翻译： 本发明提供了与UV暴露有关的新的线粒体融合转录物和相关的缺失分子。 还提供了用于体内和体外检测mtDNA分子和相关融合转录物的方法，以及它们在护肤产品的筛选和测试中的用途。
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公开(公告)号：EP2542680B1
公开(公告)日：2017-09-27
申请号：EP11750131.2
申请日：2011-03-01
发明人： HARBOTTLE, Andrew , DAKUBO, Gabriel , PARR, Ryan L. , CREED, Jennifer , REGULY, Brian , ROBINSON, Kerry
CPC分类号： C12Q1/6883 , C07K14/80 , C07K2319/00 , C12N9/0036 , C12N9/0053 , C12N9/12 , C12N9/14 , C12N15/62 , C12Q2600/148 , C12Q2600/156 , C12Y106/99003 , C12Y109/03001 , C12Y207/10001 , C12Y306/01003
摘要： The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products.
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