专利检索 ap:("MEDAREX, INC.") AND inv:"TINO, William, T." 第 1 页

1.

发明授权
MONOCLONAL ANTIBODIES SPECIFIC FOR THE EXTRACELLULAR DOMAIN OF PROSTATE SPECIFIC MEMBRANE ANTIGEN 无效
标题翻译：特异性单克隆抗体PROTASTA特异性膜抗原的胞外域

公开(公告)号：EP0914155B1

公开(公告)日：2006-02-22

申请号：EP97917121.2

申请日：1997-03-25

申请人： MEDAREX, INC.

发明人： MURPHY, Gerald, P. , BOYNTON, Alton, L. , HOLMES, Eric, H. , TINO, William, T.

IPC分类号： A61K39/395 , A61K39/40 , A61K39/42 , G01N33/574 , G01N33/53 , C07K16/00 , C12P21/08 , C07K16/28

CPC分类号： C07K16/28 , A61K38/00 , C07K2317/34 , C12N2799/026

2.

发明公开
HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) 审中-公开
标题翻译：人类单克隆抗体的前列腺特异性膜抗原（PSMA）

公开(公告)号：EP1519747A2

公开(公告)日：2005-04-06

申请号：EP03721280.0

申请日：2003-01-28

申请人： Medarex, Inc.

发明人： DEO, Yashwant, M. , GRAZIANO, Robert , HUDSON, Debra , HOLMES, Eric, H. , TINO, William, T. , BLACK, Amelia

IPC分类号： A61K39/42 , A61K39/395 , C07K14/00 , C07K16/00

CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/28 , C07K16/283 , C07K2317/21 , C07K2317/31 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77

摘要： Isolated human monoclonal antibodies which bind to PSMA, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.