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1.发明授权
公开(公告)号：EP1064303B1
公开(公告)日：2007-05-09
申请号：EP99913932.2
申请日：1999-03-18
申请人： MEDAREX, INC.
IPC分类号： C07K14/705 , C07K16/28 , A61K39/395 , G01N33/68 , A61P35/00
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K2317/34 , C12N2799/026 , Y10S435/81
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2.发明授权MONOCLONAL ANTIBODIES SPECIFIC FOR THE EXTRACELLULAR DOMAIN OF PROSTATE SPECIFIC MEMBRANE ANTIGEN 无效特异性单克隆抗体PROTASTA特异性膜抗原的胞外域
公开(公告)号：EP0914155B1
公开(公告)日：2006-02-22
申请号：EP97917121.2
申请日：1997-03-25
申请人： MEDAREX, INC.
IPC分类号： A61K39/395 , A61K39/40 , A61K39/42 , G01N33/574 , G01N33/53 , C07K16/00 , C12P21/08 , C07K16/28
CPC分类号： C07K16/28 , A61K38/00 , C07K2317/34 , C12N2799/026
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3.发明公开HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434A2
公开(公告)日：2008-08-27
申请号：EP06840172.8
申请日：2006-12-08
申请人： MEDAREX, INC.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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4.发明公开HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) 审中-公开人类单克隆抗体的前列腺特异性膜抗原（PSMA）
公开(公告)号：EP1519747A2
公开(公告)日：2005-04-06
申请号：EP03721280.0
申请日：2003-01-28
申请人： Medarex, Inc.
发明人： DEO, Yashwant, M. , GRAZIANO, Robert , HUDSON, Debra , HOLMES, Eric, H. , TINO, William, T. , BLACK, Amelia
IPC分类号： A61K39/42 , A61K39/395 , C07K14/00 , C07K16/00
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/28 , C07K16/283 , C07K2317/21 , C07K2317/31 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies which bind to PSMA, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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5.发明授权HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434B1
公开(公告)日：2012-07-11
申请号：EP06840172.8
申请日：2006-12-08
申请人： Medarex, Inc.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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公开(公告)号：EP1210374B1
公开(公告)日：2006-10-11
申请号：EP00950674.2
申请日：2000-07-26
申请人： MEDAREX, INC.
IPC分类号： C07K16/30 , C07K16/28 , A01K67/027 , A61K39/395 , G01N33/574 , C12N5/20 , C07K16/46 , A61P35/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K16/283 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1210374A1
公开(公告)日：2002-06-05
申请号：EP00950674.2
申请日：2000-07-26
IPC分类号： C07K16/30 , C07K16/28 , A01K67/027 , A61K39/395 , G01N33/574 , C12N5/20 , C07K16/46 , A61P35/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K16/283 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.
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