公开(公告)号：EP1928496A2

公开(公告)日：2008-06-11

申请号：EP06802602.0

申请日：2006-08-30

申请人： MEDIMMUNE, INC. ,  Yale University

发明人： REED, Jennifer, Lynne ,  WHITE, Wendy ,  COYLE, Anthony ,  ELIAS, Jack ,  KOZHICH, Alexander

IPC分类号： A61K39/395 ,  C07K16/44

CPC分类号： C07K16/40 ,  A61K48/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00 ,  C12N9/2442 ,  C12N15/86 ,  C12N2710/10343 ,  C12Y302/01014

摘要： The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL- 13 mediated inflammatory diseases. Accordingly the present invention provides C/CLP antagonists and also provides compositions and methods for the prevention, management, treatment or amelioration of an inflammatory condition associated with the upregulation of a C/CLP or one or more symptoms thereof and/or the inhibition of IL- 13 mediated inflammation.